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Endorphins and Opiate Antagonists in Psychiatric Research

Clinical Implications

  • Book
  • © 1982

Overview

Editors:
  1. Nandkumar S. Shah

    1. William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, Department of Pharmacology, University of South Carolina School of Medicine, Columbia, USA

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  2. Alexander G. Donald

    1. William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina School of Medicine, Columbia, USA

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Introduction Current Status of Endorphins and Opiate Antagonists in Psychiatry An Overview

    • Nandkumar S. Shah, Alexander G. Donald
    Pages 1-13

  3. The Opiate Receptor and Its Endogenous Ligands An Overview

    • Jacob M. Hiller
    Pages 15-39

  4. The Endorphins and Analgesia A Minireview

    • Thuy T. Chau
    Pages 41-59

  5. Central Nervous System Effects after Systemic Injection of Opiate Peptides

    • Richard D. Olson, Abba J. Kastin, Gayle A. Olson, David H. Coy
    Pages 61-73

  6. Possible Roles of Prostaglandins in Mediating Opioid Actions

    • David F. Horrobin
    Pages 75-87

  7. Psychoactive Agents and Enkephalin Degradation

    • Alexander Jakubovic
    Pages 89-97

  8. Relationship of Opiate Peptides to Neuroendocrine Functions

    • A. Dupont, Y. Mérand, D. Rouleau, L. Cusan, A. Lemay, H. Vaudry et al.
    Pages 99-126

  9. β-Endorphin and Central Nervous System

    • Viktor Havlicek, Michael West, Nobumasa Kato, Henry G. Friesen
    Pages 127-159

  10. Biochemical Evidence for a Role for Endorphins in Mental Illness

    • Doris H. Clouet
    Pages 161-178

  11. Opiate Receptors and Opiate Antagonists in Psychiatric and Related Research A Review

    • Jambur Ananth, Vasvan Nair, Ram Rastogi
    Pages 179-212

  12. Endorphins in Psychiatric Research and Treatment

    • W. M. A. Verhoeven, H. M. van Praag
    Pages 213-229

  13. β-Endorphin-Like Immunoreactivity in CSF and Plasma of Neuropsychiatric Patients

    • V. Höllt, H. M. Emrich, M. Bergmann, N. Nedopil, D. Dieterle, H. J. Gurland et al.
    Pages 231-243

  14. Cerebrospinal Fluid Content of Endorphins in Schizophrenia

    • L. H. Lindström, G. Besev, L-M. Gunne, R. Sjöström, L. Terenius, A. Wahlstrom et al.
    Pages 245-256

  15. Behavioral Effects of β-Endorphin in Depression and Schizophrenia

    • Robert H. Gerner, David A. Gorelick, Don H. Catlin, Cho Hao Li
    Pages 257-270

  16. Effects of Opiate Antagonists and Agonists on Behavioral and Neuroendocrine Variables

    • David S. Janowsky, Lewis L. Judd
    Pages 271-289

  17. The Narcotic Antagonists Implications for Psychiatric Research

    • Albert A. Kurland
    Pages 291-303

  18. The Use of an Oral Opiate Antagonist in Schizophrenia

    • David H. Mielke
    Pages 305-309

  19. Peptides and Amino Acids in Human Hemodialysate

    • Roberta M. Palmour, Frank R. Ervin
    Pages 311-331

  20. Dialysis of Schizophrenia

    • J. Robert Cade, Herbert Wagemaker, Alexander M. C. Macgregor
    Pages 333-345
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Keywords

About this book

The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha­ nisms mediating the synaptic action, and to the appraisal of the involve­ ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux.

Editors and Affiliations

  • William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, Department of Pharmacology, University of South Carolina School of Medicine, Columbia, USA

    Nandkumar S. Shah

  • William S. Hall Psychiatric Institute, Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina School of Medicine, Columbia, USA

    Alexander G. Donald

Bibliographic Information

  • Book Title: Endorphins and Opiate Antagonists in Psychiatric Research

  • Book Subtitle: Clinical Implications

  • Editors: Nandkumar S. Shah, Alexander G. Donald

  • DOI: https://doi.org/10.1007/978-1-4684-1119-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Publishing Corporation 1982

  • Softcover ISBN: 978-1-4684-1121-8Published: 17 February 2012

  • eBook ISBN: 978-1-4684-1119-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 510

  • Number of Illustrations: 41 b/w illustrations

  • Topics: Business and Management, general

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