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Endorphins and Opiate Antagonists in Psychiatric Research

Clinical Implications

Authors: Shah, Nandkumar S., Donald, Alexander G.

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About this book

The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha­ nisms mediating the synaptic action, and to the appraisal of the involve­ ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux.

Table of contents (28 chapters)

Table of contents (28 chapters)
  • Introduction Current Status of Endorphins and Opiate Antagonists in Psychiatry An Overview

    Pages 1-13

    Shah, Nandkumar S. (et al.)

  • The Opiate Receptor and Its Endogenous Ligands An Overview

    Pages 15-39

    Hiller, Jacob M.

  • The Endorphins and Analgesia A Minireview

    Pages 41-59

    Chau, Thuy T.

  • Central Nervous System Effects after Systemic Injection of Opiate Peptides

    Pages 61-73

    Olson, Richard D. (et al.)

  • Possible Roles of Prostaglandins in Mediating Opioid Actions

    Pages 75-87

    Horrobin, David F.

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-1119-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-1121-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Endorphins and Opiate Antagonists in Psychiatric Research
Book Subtitle
Clinical Implications
Authors
Copyright
1982
Publisher
Springer US
Copyright Holder
Plenum Publishing Corporation
eBook ISBN
978-1-4684-1119-5
DOI
10.1007/978-1-4684-1119-5
Softcover ISBN
978-1-4684-1121-8
Edition Number
1
Number of Pages
510
Number of Illustrations
41 b/w illustrations
Topics