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Advances in Experimental Medicine and Biology

Cytochromes P-450 and b5

Structure, Function, and Interaction

Editors: Cooper, David (Ed.)

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About this book

P-450 has in common with our nation that it can call Phila­ delphia its hometown. Yet there are differences, too. The U. S. A. was born and named in this city. P-450 was first recog­ nized here -- an odd CO-combining pigment without family or func­ tion. Japanese workers identified it as an unusual member of the cytochrome family. Finally, in Philadelphia, its biological func­ tion was established and its growth to a global power initiated. Since discovery of its function as terminal oxidase of the 21-steroid hydroxylase system of adrenocortical microsomes, P-450 has proved to play the same role in a wide variety of other mixed function oxidase systems involved in biosynthesis and catabolism of specific cell or body components as well as in the metabolism of foreign substances entering organisms. P-450-like oxygenating enzymes appear to be fundamental cellular constituents in most forms of aerobic organisms. Activation of molecular oxygen and incorporation of one of its atoms into organic compounds as cata­ lyzed by P-450 enzymes are reactions of vital importance not only for biosynthesis and degradation of steroid hormones necessary for sustaining life, but also for metabolic activation or inactivation of foreign agents such as drugs, food preservatives and additives, insecticides and carcinogens. Moreover, P-450 linked enzyme sys­ tems can either be induced or suppressed by these agents with significant biological consequences.

Table of contents (34 chapters)

Table of contents (34 chapters)
  • Partial Purification and Separation of Multiple Forms of Cytochrome P-450 and Cytochrome P-448 from Rat Liver Microsomes

    Pages 1-24

    Levin, W. (et al.)

  • Biochemical Characterization of Highly Purified Cytochrome P-450 and Other Components of the Mixed Function Oxidase System of Liver Microsomal Membranes

    Pages 25-46

    Coon, Minor J. (et al.)

  • Immunochemical and Compositional Comparison of Cytochrome P-450cam of Pseudomonas Putida and P-450LM of Phenobarbital-Induced Rabbit Liver Microsomes

    Pages 47-53

    Dus, Karl (et al.)

  • Immunochemical and Functional Similarities and Differences among Iron-Sulfur Proteins Involved in Mammalian Steroidogenesis

    Pages 55-71

    Baron, Jeffrey

  • General Discussion

    Pages 73-80

    Cooper, David Y. (et al.)

Buy this book

eBook $84.99
price for USA in USD
  • ISBN 978-1-4615-9026-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4615-9028-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cytochromes P-450 and b5
Book Subtitle
Structure, Function, and Interaction
Editors
  • David Cooper
Series Title
Advances in Experimental Medicine and Biology
Series Volume
58
Copyright
1975
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-9026-2
DOI
10.1007/978-1-4615-9026-2
Softcover ISBN
978-1-4615-9028-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIII, 554
Topics

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