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Advances in General and Cellular Pharmacology

Volume 1

Authors: Narahashi, Toshio, Bianchi, C. Paul

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About this book

Knowledge of the mechanism of action of drugs at cellular, subcellular, or molecular levels is of vital importance not only in giving the basis of inter­ pretation of the systemic action of drugs but also in improving existing drugs; in designing new forms of drugs; and in giving the basis of therapeutic applications. Classical pharmacology, concerning the action of drugs at integrated levels, does not necessarily give sufficient information as to the mechanism of action of drugs. A variety of sophisticated concepts utilizing the methods of physics, chemistry, biophysics, biochemistry, and physiology must be synthesized to understand the mechanism of action. Only since the last decade, however, have these techniques been fully applied to pharma­ cological investigations. It is of utmost importance to realize that a new dimension of pharmacological research has indeed emerged as a result of such a multidisciplinary approach; this approach is encompassed in general and cellular pharmacology. Such recent studies of drug actions have led to a number of important findings. Certain chemicals and drugs were found to possess highly specific actions on cellular functions, so that they are widely being used as powerful tools for the study of a variety of physiological and pharmacological prob­ lems. Our knowledge of the cellular mechanisms of drug action has provided the basis for interpreting the systemic effects of the drugs and insight into the molecular mechanism involved.

Table of contents (5 chapters)

Table of contents (5 chapters)
  • Cardiac Cellular Pharmacology: Automaticity in Cardiac Muscle—Its Alteration by Physical and Chemical Influences

    Pages 1-66

    Weld, Francis M. (et al.)

  • Actions of Opiates and Their Antagonists on Cholinergic Transmission in the Guinea Pig Ileum

    Pages 67-82

    Ehrenpreis, Seymour

  • Pharmacology of Heart Cells During Ontogenesis

    Pages 83-144

    Pappano, Achilles J.

  • Analysis of Dose—Response Relationships

    Pages 145-178

    Waud, Douglas R.

  • Cellular Pharmacology of Ganglionic Transmission

    Pages 179-245

    Nishi, Syogoro

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4615-8198-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4615-8200-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Advances in General and Cellular Pharmacology
Book Subtitle
Volume 1
Authors
Copyright
1976
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4615-8198-7
DOI
10.1007/978-1-4615-8198-7
Softcover ISBN
978-1-4615-8200-7
Edition Number
1
Number of Pages
XI, 252
Number of Illustrations
28 b/w illustrations
Topics