Immunodermatology

1. Front Matter

   Pages i-xlii

   PDF

2. Cell-Mediated Immunity

   • Susanna Cunningham-Rundles

   Pages 1-33

3. Antigens and Immunogens

   • Frederic C. McDuffie

   Pages 35-45

4. Humoral Immunity in Comprehensive Immunology

   • Charlotte Cunningham-Rundles

   Pages 47-63

5. The Complement System

   • Irma Gigli

   Pages 65-100

6. Mechanisms of Nonspecific Host Resistance

   • Ralph Snyderman, Marilyn C. Pike

   Pages 101-114

7. The HLA System and Dermatological Diseases

   • Bo Dupont

   Pages 115-128

8. Natural Control over Immune Responses

   • Stanley A. Schwartz, K. Murali Krishna Rao

   Pages 129-140

9. Mechanisms of Tissue Injuries and Repairs in Hypersensitivity

   • Michael E. Miller

   Pages 141-150

10. Cyclic Nucleotides, Arachidonic Acid, and Polyamines in the Pathophysiology of Inflammatory Proliferative Skin Diseases

    • John J. Voorhees

    Pages 151-160

11. Prostaglandins and Other Arachidonate Metabolites

    • Robert B. Zurier, Peter W. Ramwell

    Pages 161-175

12. Role of Proteinases in Cutaneous Inflammation

    • Gerald S. Lazarus, Roderick M. Farb, Charlotte A. Thomas

    Pages 177-187

13. Collagen Biosynthesis and Connective Tissue Abnormalities

    • Ervin H. Epstein Jr.

    Pages 189-196

14. Vasculitis

    • W. Mitchell Sams Jr.

    Pages 197-215

15. Adverse Drug Reactions

    • Michael J. Fellner

    Pages 217-227

16. The Graft-vs.-Host Reaction in Man

    • John A. Hansen, James M. Woodruff, Robert A. Good

    Pages 229-257

17. Allergic Contact Dermatitis, Photoallergic Contact Dermatitis, and Phototoxic Dermatitis

    • Rudolf L. Baer, David R. Bickers

    Pages 259-271

18. Urticaria/Angioedema

    • Nicholas A. Soter, K. Frank Austen

    Pages 273-292

19. Eosinophil in Skin Disorders

    • Dorothea Zucker-Franklin

    Pages 293-299

20. Atopic Dermatitis

    • Jon M. Hanifin

    Pages 301-311

By 1940, immunological mechanisms had been proved to have fundamental influ­ ences on a great number and variety of skin reactions, and skin diseases had brought to light a great number of fundamental immunological mechanisms that were basic to a wide range of different diseases, dermatological and nondermato­ logical. The preeminence of dermatological research in the advancement of immu­ nological knowledge should not astonish anyone. For the skin is not only the most easily accessible tissue for producing and studying immunological reactions, it is also the great organ of protection that meets the first onslaughts of inimical environmental forces and agents-potential enemies, both living and dead. And protection is in essence what immunology is all about. To get an idea of the long-established role that testing the skin and the study of its many reactions has played in advancing general immunology, one need recall only smallpox vaccination; tuberculin testing; testing with fungal extracts; skin testing in hay fever, asthma, and serum sickness; skin tests with toxins and toxoids; the patch test; the passive transfer of skin-adhering antibodies (reagins); skin sensitization by simple chemicals; and similar dermatological procedures that have exerted their influence on medical and scientific disciplines far beyond dermatology.

• antibody
• asthma
• dermatology
• diseases
• immunology
• skin
• skin disease
• vaccination

• Memorial Sloan-Kettering Cancer Center, New York, USA

  Bijan Safai, Robert A. Good

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