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Molecular Pathogenesis of Colorectal Cancer

  • Book
  • © 2013

Overview

Editors:
  1. Kevin M. Haigis, Ph.D.

    1. Molecular Pathology Unit, Harvard Medical School, Charlestown, USA

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  • Identification and characterization of targetable oncogenic pathways in colorectal cancer

  • Discussion of the current and future prospects for targeting that pathway therapeutically

  • Emerging technologies for identifying new cancer related genes, and therefore new therapeutic targets

  • Includes supplementary material: sn.pub/extras

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Genetics of Colorectal Cancer

    • William Hankey, Joanna Groden
    Pages 1-24

  3. Molecular Mechanisms of Colorectal Carcinogenesis

    • Jatin Roper, Kenneth E. Hung
    Pages 25-65

  4. The Association Between Inflammation and Colorectal Cancer

    • Maria José Oliveira, Sérgia Velho
    Pages 67-105

  5. Importance of the Niche: Wnt Signaling and Stem Cell Plasticity in Intestinal Homeostasis and Disease

    • Owen J. Sansom, Inke Näthke
    Pages 107-120

  6. Mutational Activation of KRAS and BRAF in Colorectal Cancer

    • Katherine H. Pedone, Jennifer L. Sells, Channing J. Der
    Pages 121-156

  7. The PI3K Pathway in Colorectal Cancers

    • Jihye Yun, George Poulogiannis, Evan T. Brower, Samuel Klempner, Lewis L. Cantley
    Pages 157-199

  8. TGF-ß Signaling Pathway and Colorectal Cancer

    • William M. Grady
    Pages 201-230

  9. The Clinical Significance of Mutations in Colorectal Cancer

    • Franklin W. Huang, Laura B. Kleiman, Theodore S. Hong
    Pages 231-245

  10. Colorectal Cancer Genome and Its Implications

    • Nickolas Papadopoulos
    Pages 247-265

  11. Copy-Number Alterations in the Colorectal Cancer Genome

    • Jihun Kim, Adam J. Bass
    Pages 267-287

  12. Genome-Wide Association Studies in Colorectal Cancer

    • Ian Tomlinson
    Pages 289-302

  13. Future Prospects for Leveraging Molecular Information in the Fight Against Colorectal Cancer

    • Laura B. Kleiman, Kevin M. Haigis
    Pages 303-308

  14. Back Matter

    Pages 309-316
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About this book

Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.

Editors and Affiliations

  • Molecular Pathology Unit, Harvard Medical School, Charlestown, USA

    Kevin M. Haigis, Ph.D.

Bibliographic Information

  • Book Title: Molecular Pathogenesis of Colorectal Cancer

  • Editors: Kevin M. Haigis, Ph.D.

  • DOI: https://doi.org/10.1007/978-1-4614-8412-7

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-8411-0Published: 03 October 2013

  • Softcover ISBN: 978-1-4939-4278-7Published: 23 August 2016

  • eBook ISBN: 978-1-4614-8412-7Published: 02 October 2013

  • Edition Number: 1

  • Number of Pages: VIII, 316

  • Number of Illustrations: 1 b/w illustrations, 29 illustrations in colour

  • Topics: Cancer Research, Molecular Medicine, Protein Science, Cell Biology

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