Epigenetics and Complex Traits
Editors: Naumova, Anna K., Greenwood, Celia MT (Eds.)
Free Preview- Focuses on the relationship between epigenetic changes and genetic changes in human disease
- A resource for those working in human genetics to learn of the impact epigenetics has on inheritance
- Presents detailed and distinct views on the interplay between complex traits and epigenetics
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- About this book
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This book will provide an overview of basic epigenetic phenomena; interaction between epigenetic and genetic factors; and the influence of epigenetic factors on inheritance. Epigenetic states may contribute to the penetrance of genetic polymorphisms or mutations and thereby modify inheritance patterns. This may result in non‐Mendelian inheritance of genetic traits such as observed in common human disease. The relationship between epigenetics and genetics, however, has not been comprehensively summarized yet. The topic is being more and more appreciated lately due to considerable advances in genomic and epigenomic approaches to study the origins of human disease. The editors will focus not only on describing epigenetic characteristics, mechanisms and results, but also on how considerations of epigenetics can alter interpretation and analysis of risks for complex traits. This book will be a resource for those who have been working in human genetics or analysis of human genetic data and are studying the impact of epigenetics on inheritance. An overview will be given of the impacts of inter‐individual variation in epigenetic states from major changes (errors in genomic imprinting) that cause congenital developmental defects to subtle changes and their impact on complex traits. The editors will discuss the relationship between epigenetic changes and genetic changes in human disease. Several chapters will also focus on statistical analysis of epigenetics effects, either in human disease genetic studies, or in population genetics.
- Table of contents (14 chapters)
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Epigenetic Reprogramming in the Mammalian Germline
Pages 3-34
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Establishment of Tissue-Specific Epigenetic States During Development
Pages 35-62
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X-Chromosome Inactivation
Pages 63-88
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Cis- and Trans-Effects Underlying Polar Overdominance at the Callipyge Locus
Pages 89-106
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Transgenerational Epigenetic Effects and Complex Inheritance Patterns
Pages 107-129
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Table of contents (14 chapters)
- Download Preface 1 PDF (24.3 KB)
- Download Sample pages 1 PDF (629.5 KB)
- Download Table of contents PDF (25.5 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Epigenetics and Complex Traits
- Editors
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- Anna K. Naumova
- Celia MT Greenwood
- Copyright
- 2013
- Publisher
- Springer-Verlag New York
- Copyright Holder
- Springer Science+Business Media New York
- eBook ISBN
- 978-1-4614-8078-5
- DOI
- 10.1007/978-1-4614-8078-5
- Hardcover ISBN
- 978-1-4614-8077-8
- Softcover ISBN
- 978-1-4939-4487-3
- Edition Number
- 1
- Number of Pages
- XXII, 341
- Number of Illustrations
- 10 b/w illustrations, 33 illustrations in colour
- Topics
