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Advances in Chronic Lymphocytic Leukemia

  • Book
  • © 2013

Overview

Editors:
  1. Sami Malek

    1. Department of Internal Medicine, University of Michigan, Ann Arbor, USA

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  • Provides a comprehensive review on chronic lymphocytic leukemia
  • Features paramount research in the field
  • Focuses on crucial aspects of CLL pathogenesis
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 792)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xi
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  2. B Cell Receptor and Antigens in CLL

    • Andreas Agathangelidis, Stavroula Ntoufa, Kostas Stamatopoulos
    Pages 1-24

  3. The CLL Cell Microenvironment

    • Jan A. Burger
    Pages 25-45

  4. Acquired Genomic Copy Number Aberrations in CLL

    • Peter Ouillette, Sami Malek
    Pages 47-86

  5. Recurrent Gene Mutations in CLL

    • Alejandra Martínez-Trillos, Víctor Quesada, Neus Villamor, Xose S. Puente, Carlos López-Otín, Elías Campo
    Pages 87-107

  6. TP53 Aberrations in Chronic Lymphocytic Leukemia

    • Martin Trbusek, Jitka Malcikova
    Pages 109-131

  7. Gene Expression and Epigenetic Deregulation

    • Rita Shaknovich
    Pages 133-150

  8. Apoptosis Deregulation in CLL

    • Chris Fegan, Chris Pepper
    Pages 151-171

  9. Richter Syndrome

    • Davide Rossi, Gianluca Gaidano
    Pages 173-191

  10. Molecular Biomarkers in Chronic Lymphocytic Leukemia

    • Sami Malek
    Pages 193-214

  11. Critical Signal Transduction Pathways in CLL

    • Asish K. Ghosh, Neil E. Kay
    Pages 215-239

  12. Immunotherapies in CLL

    • Jae H. Park, Renier J. Brentjens
    Pages 241-257

  13. Towards Targeted Therapy of Chronic Lymphocytic Leukemia

    • Carsten U. Niemann, Jade Jones, Adrian Wiestner
    Pages 259-291

  14. Inherited Susceptibility to CLL

    • Helen E. Speedy, Georgina Sava, Richard S. Houlston
    Pages 293-308

  15. miR Deregulation in CLL

    • Veronica Balatti, Yuri Pekarky, Lara Rizzotto, Carlo M. Croce
    Pages 309-325

  16. Back Matter

    Pages 327-334
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Keywords

About this book

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course.  While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL.  In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings.  This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply.  Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings.

We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia. 

Editors and Affiliations

  • Department of Internal Medicine, University of Michigan, Ann Arbor, USA

    Sami Malek

About the editor

Sami N. Malek is an Associate Professor at the Department of Internal Medicine at the University of Michigan Health System. Dr. Malek's research interests include basic and translational questions in Leukemia and Lymphoma. Well known in the field of CLL, Dr. Malek is well-published in the area and is invited to international conferences and seminars to give talks on the topic.

Bibliographic Information

  • Book Title: Advances in Chronic Lymphocytic Leukemia

  • Editors: Sami Malek

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-8051-8

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2013

  • Hardcover ISBN: 978-1-4614-8050-1Published: 07 September 2013

  • Softcover ISBN: 978-1-4939-5389-9Published: 23 August 2016

  • eBook ISBN: 978-1-4614-8051-8Published: 07 September 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XI, 334

  • Number of Illustrations: 1 b/w illustrations, 24 illustrations in colour

  • Topics: Cancer Research

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