Overview
- Provides first systematic overview of structure, function and regulation of DNA helicases
- Integrates knowledge obtained through diverse technical approaches
- Gives a unified view on how helicases function in the cell and are regulated in response to different cellular stresses
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 767)
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Table of contents (14 chapters)
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Front Matter
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Back Matter
About this book
In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines.
The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.Editors and Affiliations
Bibliographic Information
Book Title: DNA Helicases and DNA Motor Proteins
Editors: Maria Spies
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4614-5037-5
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2013
Hardcover ISBN: 978-1-4614-5036-8Published: 17 November 2012
Softcover ISBN: 978-1-4899-9851-4Published: 23 December 2014
eBook ISBN: 978-1-4614-5037-5Published: 19 November 2012
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XII, 299
Number of Illustrations: 11 b/w illustrations, 58 illustrations in colour
Topics: Human Genetics, Biochemistry, general, Cell Biology, Biomedicine, general