Systems Biology of Apoptosis

1. Front Matter

   Pages i-xii

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2. Modeling Formalisms in Systems Biology of Apoptosis

   • Stefan Kallenberger, Stefan Legewie

   Pages 1-32

3. Systems Biology of Death Receptor-Induced Apoptosis

   • Kolja Schleich, Inna N. Lavrik

   Pages 33-56

4. Systematic Complexity Reduction of Signaling Models and Application to a CD95 Signaling Model for Apoptosis

   • Dennis Rickert, Nicolai Fricker, Inna N. Lavrik, Fabian J. Theis

   Pages 57-84

5. Systems Biology of the Mitochondrial Apoptosis Pathway

   • Jochen H. M. Prehn, Heinrich J. Huber, Carla O’Connor

   Pages 85-99

6. Systems Biology of Cell Death in Hepatocytes

   • Rebekka Schlatter, Kathrin Schmich, Christoph Borner, Michael Ederer, Irmgard Merfort

   Pages 101-123

7. Understanding Different Types of Cell Death Using Systems Biology

   • Laurence Calzone, Andrei Zinovyev, Boris Zhivotovsky

   Pages 125-143

8. Modeling Single Cells in Systems Biology

   • Nicolai Fricker, Inna N. Lavrik

   Pages 145-161

9. Cytokine–Cytokine Cross Talk and Cell-Death Decisions

   • Christopher D. Deppmann, Kevin A. Janes

   Pages 163-180

10. Genetic and Genomic Dissection of Apoptosis Signaling

    • Christina Falschlehner, Michael Boutros

    Pages 181-197

11. Back Matter

    Pages 199-203

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Systems Biology of Apoptosis summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.

• Apoptosis
• Systems Biology

• Otto von Guericke University, Department of Translational Inflammation, Institute of Experimental Internal Medic, Magdeburg, Germany

  Inna N. Lavrik

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