LC-MS in Drug Bioanalysis

1. Front Matter

   Pages i-xi

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2. Internal Standards for Quantitative LC-MS Bioanalysis

   • Aimin Tan, Nadine Boudreau, Ann Lévesque

   Pages 1-32

3. Method Development, Validation, and Sample Analysis for Regulated Quantitative Bioanalysis Using LC-MS/MS

   • Min Meng, Patrick K. Bennett

   Pages 33-66

4. Impact of Sampling Paper/Cards on Bioanalytical Quantitation via Dried Blood Spots by Liquid Chromatography-Mass Spectrometry

   • Jun Zhang, Ramona Rodila, Huaiqin Wu, Tawakol A. El-Shourbagy

   Pages 67-80

5. Highly Sensitive Pharmaceutical and Clinical Analysis Using Selective Solid-Phase Extraction Coupled to Microflow Liquid Chromatography and Isotope-Dilution Mass Spectrometry

   • Haoying Yu, Xiaotao Duan, Jun Qu

   Pages 81-107

6. Pitfalls of LC-MS/MS in the Clinical Laboratory

   • Christoph Seger, Michael Vogeser

   Pages 109-126

7. Therapeutic Drug Monitoring to Support Clinical Pharmacogenomics

   • Alan H. B. Wu, Kara L. Lynch

   Pages 127-141

8. Liquid Chromatography-Mass Spectrometry for the Determination of Antidepressants and Some of their Major Metabolites in Human Biological Matrices

   • Ana de Castro, Angelines Cruz, Manuel López-Rivadulla

   Pages 143-175

9. The Analysis of Antipsychotic Drugs in Human Biosamples by LC-MS

   • Eva Saar, Dimitri Gerostamoulos, Olaf H. Drummer, Jochen Beyer

   Pages 177-195

10. Therapeutic Drug Monitoring of Targeted Anticancer Therapy. Tyrosine Kinase Inhibitors and Selective Estrogen Receptor Modulators: A Clinical Pharmacology Laboratory Perspective

    • Laurent Decosterd, Elyes Dahmane, Marine Neeman, Thierry Buclin, Chantal Csajka, Amina Haouala et al.

    Pages 197-250

11. Applications of Mass Spectrometry in Analyses of Steroid Hormones

    • Zimeng Yan, Chang Cheng, Shaorong Liu

    Pages 251-286

12. Liquid Chromatography-Mass Spectrometric Analysis of Tropane Alkaloids in Mammalian Samples: Techniques and Applications

    • Harald John

    Pages 287-347

13. Analysis of Illicit Drugs in Human Biological Samples by LC-MSⁿ

    • Manuel Sergi, Sabino Napoletano

    Pages 349-398

14. Use of Matrix Assisted Laser Desorption/Ionization Imaging Mass Spectrometry (MALDI-IMS) in the Development of Novel Small Molecule Drugs

    • Jihai Pang, Timothy L. Madden

    Pages 399-422

15. A Planar Integrated Micro-mass Spectrometer

    • Jörg Müller, Grigoriy Quiring, Maria Reinhardt-Szyba, Régulo Miguel Ramírez Wong, Henning Wehrs

    Pages 423-465

16. Back Matter

    Pages 467-469

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Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.

• Bioanalysis
• LC-MS
• LC-MS/MS
• Liquid chromatography
• MS
• anticancer drugs
• antidementia drugs
• antidepressants
• antiepileptic drugs
• antifundal drugs
• antimicrobial drugs
• antipsychotic drugs
• antiretroviral Drugs
• anxiolytic/hypnotic drugs
• cardiac drugs
• drugs for addiction
• immunosuppressants
• mass spectrometry
• metabolites
• mood stabilizers

• , Department of Experimental Therapeutics, University of Texas MD Anderson Cancer C, Houston, USA

  Q. Alan Xu, Timothy L. Madden

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