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Novel Developments in Stem Cell Mobilization

Focus on CXCR4

Editors: Fruehauf, Stefan, Zeller, W Jens, Calandra, Gary (Eds.)

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  • A concise review of the current status of knowledge and future developments of CXCR4 will be presented
  • Contributors are internationally leaders in the field
  • A comprehensive treatment of the subject with numerous color illustrations
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eBook $149.00
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  • ISBN 978-1-4614-1960-0
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  • ISBN 978-1-4899-9376-2
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About this book

Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell mobilization of lymphoma and myeloma patients. This allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical studies a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. Clinical studies are under way. CXCR4 antagonists are an exciting new class of compounds which are also employed for the mobilization of angiogenic cells or for the treatment of solid tumors. In this book a concise review of the current status of knowledge and future developments will be presented.

Table of contents (24 chapters)

Table of contents (24 chapters)
  • Preclinical Experience with AMD3100 for Mobilization of Hematopoietic Stem and Progenitor Cells

    Pages 3-22

    Broxmeyer, Hal E., PhD

  • Molecular Pharmacology of CXCR4 Inhibition

    Pages 23-35

    Steen, Anne (et al.)

  • Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors

    Pages 37-54

    Harun, Nadia (et al.)

  • Should We Stay or Should We Go Now?

    Pages 55-69

    Buss, Eike C. (et al.)

  • Role of the CXCR4/CXCL12 Axis in Hematopoietic Stem Cell Trafficking

    Pages 71-85

    Peled, Amnon (et al.)

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-1-4614-1960-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4614-1959-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-1-4899-9376-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Novel Developments in Stem Cell Mobilization
Book Subtitle
Focus on CXCR4
Editors
  • Stefan Fruehauf
  • W Jens Zeller
  • Gary Calandra
Copyright
2012
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-1960-0
DOI
10.1007/978-1-4614-1960-0
Hardcover ISBN
978-1-4614-1959-4
Softcover ISBN
978-1-4899-9376-2
Edition Number
1
Number of Pages
XIV, 498
Topics

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