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Self and Nonself

  • Book
  • © 2012

Overview

Editors:
  1. Carlos López-Larrea

    1. Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain

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  • Covers different aspects of the emergence of immune systems in the evolution of life
  • Focuses on the origin of the immune response during the development of multicellularity
  • Presents an integrated view of self and nonself recognition systems in the context of evolution

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 738)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xxi
    Download chapter PDF

  2. The Origin of the Bacterial Immune Response

    • Jesús Martínez-Borra, Segundo González, Carlos López-Larrea
    Pages 1-13

  3. The Evolution of Self During the Transition to Multicellularity

    • Aurora M. Nedelcu
    Pages 14-30

  4. Glyconectin Glycans as the Self-Assembling Nano-Molecular-Velcrosystem Mediating Self-Nonself Recognition and Adhesion Implicated in Evolution of Multicellularity

    • Gradimir N. Misevic, Nikola Misevic, Octavian Popescu
    Pages 31-45

  5. Neglected Biological Features in Cnidarians Self-Nonself Recognition

    • Baruch Rinkevich
    Pages 46-59

  6. Intracellular Inflammatory Sensors for Foreign Invaders and Substances of Self-Origin

    • Nao Jounai, Kouji Kobiyama, Fumihiko Takeshita
    Pages 60-78

  7. Nonself Perception in Plant Innate Immunity

    • Ian A. Dubery, Natasha M. Sanabria, Ju-Chi Huang
    Pages 79-107

  8. How did Flowering Plants Learn to Avoid Blind Date Mistakes?

    • Philip J. Kear, Bruce McClure
    Pages 108-123

  9. Signaling Pathways that Regulate Life and Cell Death: Evolution of Apoptosis in the Context of Self-Defense

    • Cristina Muñoz-Pinedo
    Pages 124-143

  10. Sensing Necrotic Cells

    • Yasunobu Miyake, Sho Yamasaki
    Pages 144-152

  11. Sensing Endoplasmic Reticulum Stress

    • Vipul M. Parmar, Martin Schröder
    Pages 153-168

  12. Autophagy and Self-Defense

    • Jesús Martínez-Borra, Carlos López-Larrea
    Pages 169-184

  13. Viruses and Host Evolution: Virus-Mediated Self Identity

    • Luis Villarreal
    Pages 185-217

  14. The Evolution of Adaptive Immunity

    • Nadia Danilova
    Pages 218-235

  15. Epigenetic Code and Self-Identity

    • Vincenzo Calvanese, Ester Lara, Mario F. Fraga
    Pages 236-255

  16. Viral Immunomodulatory Proteins: Usurping Host Genes as a Survival Strategy

    • Pablo Engel, Ana Angulo
    Pages 256-276

  17. The Emergence of the Major Histocompatilibility Complex

    • Jesús Martínez-Borra, Carlos López-Larrea
    Pages 277-289

  18. MHC Signaling during Social Communication

    • James S. Ruff, Adam C. Nelson, Jason L. Kubinak, Wayne K. Potts
    Pages 290-313

  19. Back Matter

    Pages 315-320
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Keywords

About this book

In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.

Editors and Affiliations

  • Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain

    Carlos López-Larrea

About the editor

Carlos López-Larrea is Professor of Immunology (Oviedo, Spain) and currently Head of the Department of Immunology at the Hospital Universitario Central de Asturias (Oviedo, Spain). He is a world expert on spondyloarthropathies (SpA), in particular genetic (MHC) and genetic factors that influence the development of the disease. The main research interests of his group also currently include the study of epigenetic mechanisms involved in autoimmune diseases and the role of innate immunity in organ transplantation tolerance. He is a member of several international scientific organizations and board member of different scientific journals. He has published more than 150 international papers and books related to immunology and spondylaorthropathies.

Bibliographic Information

  • Book Title: Self and Nonself

  • Editors: Carlos López-Larrea

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-1680-7

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2012

  • Hardcover ISBN: 978-1-4614-1679-1Published: 30 January 2012

  • Softcover ISBN: 978-1-4939-4343-2Published: 23 August 2016

  • eBook ISBN: 978-1-4614-1680-7Published: 07 March 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXII, 320

  • Topics: Immunology, Biomedicine general

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