Don’t miss it: Get 40% off Education & Linguistics books! Save through November 30, 2018.

Advances in Experimental Medicine and Biology

Self and Nonself

Editors: López-Larrea, Carlos (Ed.)

  • Covers different aspects of the emergence of immune systems in the evolution of life
  • Focuses on the origin of the immune response during the development of multicellularity
  • Presents an integrated view of self and nonself recognition systems in the context of evolution
see more benefits

Buy this book

eBook $179.00
price for USA in USD (gross)
  • ISBN 978-1-4614-1680-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-1-4614-1679-1
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Softcover $229.99
price for USA in USD
  • ISBN 978-1-4939-4343-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.

About the authors

Carlos López-Larrea is Professor of Immunology (Oviedo, Spain) and currently Head of the Department of Immunology at the Hospital Universitario Central de Asturias (Oviedo, Spain). He is a world expert on spondyloarthropathies (SpA), in particular genetic (MHC) and genetic factors that influence the development of the disease. The main research interests of his group also currently include the study of epigenetic mechanisms involved in autoimmune diseases and the role of innate immunity in organ transplantation tolerance. He is a member of several international scientific organizations and board member of different scientific journals. He has published more than 150 international papers and books related to immunology and spondylaorthropathies.

Table of contents (17 chapters)

  • The Origin of the Bacterial Immune Response

    Martínez-Borra, Jesús (et al.)

    Pages 1-13

  • The Evolution of Self During the Transition to Multicellularity

    Nedelcu, Aurora M.

    Pages 14-30

  • Glyconectin Glycans as the Self-Assembling Nano-Molecular-Velcrosystem Mediating Self-Nonself Recognition and Adhesion Implicated in Evolution of Multicellularity

    Misevic, Gradimir N. (et al.)

    Pages 31-45

  • Neglected Biological Features in Cnidarians Self-Nonself Recognition

    Rinkevich, Baruch

    Pages 46-59

  • Intracellular Inflammatory Sensors for Foreign Invaders and Substances of Self-Origin

    Jounai, Nao (et al.)

    Pages 60-78

Buy this book

eBook $179.00
price for USA in USD (gross)
  • ISBN 978-1-4614-1680-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-1-4614-1679-1
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Softcover $229.99
price for USA in USD
  • ISBN 978-1-4939-4343-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Self and Nonself
Editors
  • Carlos López-Larrea
Series Title
Advances in Experimental Medicine and Biology
Series Volume
738
Copyright
2012
Publisher
Springer-Verlag New York
Copyright Holder
Landes Bioscience and Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-1680-7
DOI
10.1007/978-1-4614-1680-7
Hardcover ISBN
978-1-4614-1679-1
Softcover ISBN
978-1-4939-4343-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXII, 320
Topics