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Chronic Hepatitis C Virus

Advances in Treatment, Promise for the Future

  • Book
  • © 2012

Overview

Editors:
  1. Mitchell L. Shiffman

    1. Bon Secours Health System, Liver Institute of Virginia, Newport News, USA

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  • New anti-viral therapy explored

  • Outlines monumental advances in treatment

  • Presents current and future treatment options

  • Includes supplementary material: sn.pub/extras

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Natural History of Chronic HCV

    1. Front Matter

      Pages 1-1
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    2. Epidemiology of Chronic HCV

      • Gary L. Davis
      Pages 3-11

    3. Acute HCV

      • Katja Deterding, Heiner Wedemeyer, Michael P. Manns
      Pages 13-20

    4. Assessing the Progression of Chronic HCV to Cirrhosis

      • Gonzolo Crespo, Stella M. Martinez, Xavier Forns
      Pages 21-33

    5. Chronic HCV and Steatosis

      • Dawn McDowell Torres, Stephen A. Harrison
      Pages 35-45

    6. Chronic HCV and Hepatocellular Carcinoma

      • Morris Sherman
      Pages 47-60

    7. Extrahepatic Manifestations of Chronic HCV

      • Vincenza Calvaruso, Antonio Craxì
      Pages 61-73

    8. Chronic HCV and HIV Coinfection

      • Patrick Ingiliz, Maud Lemoine, Yves Benhamou
      Pages 75-91

    9. Chronic HCV in Patients with Renal Disease

      • Paul Martin, Fabrizio Fabrizi
      Pages 93-102

    10. Does Treatment Alter the Natural History of Chronic HCV?

      • Fasiha Kanwal, Bruce R. Bacon
      Pages 103-112

  3. Treatment of Chronic HCV with Interferon-Based Therapy

    1. Front Matter

      Pages 113-113
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  4. Treatment of Chronic HCV with Interferon Based Therapy

    1. Treatment with Interferon and Ribavirin

      • William Kemp, Stuart K. Roberts
      Pages 115-130

    2. Immune Modulators and Other Agents

      • Edgar D. Charles, Ira M. Jacobson
      Pages 131-148

    3. Measuring HCV RNA and Assessing Virologic Response

      • Jean-Michel Pawlotsky
      Pages 149-157

    4. Response-Guided Therapy

      • Mitchell L. Shiffman
      Pages 159-169

    5. Managing the Side Effects of Therapy

      • Curtis Cooper
      Pages 171-182

    6. The Genetics of Virologic Response

      • Alison B. Jazwinski, Andrew J. Muir
      Pages 183-192

    7. Maintenance Therapy with Peginterferon

      • Raza Malik, Nezam H. Afdhal
      Pages 193-200

  5. Anti-Viral Therapy for Chronic HCV

    1. Front Matter

      Pages 201-201
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Keywords

About this book

Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.

Reviews

From the reviews:

“This book is an important contribution to the field. … This well-written, concise, and current book will find a home on the shelves of many hepatologists and gastroenterologists. In addition, because it is so readable, it should be useful for students, GI/hepatology fellows, and midlevel providers dealing with patients and doing research. … This is a concise, updated, and well-written book that belongs in the libraries of healthcare providers and researchers in the field of HCV infection as well as medical institutions.” (Paul Angulo, Doody’s Review Service, November, 2012)

“Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future represents a timely new text that is focused on the natural history, treatment, and liver transplantation for chronic hepatitis C virus (HCV) infection. … an excellent background reference for MD and PhD students, trainees, and clinicians in understanding the scientific basis for current management of chronic HCV infection and highlighting key areas for future investigation. … is a welcome addition to any library and true to its name … .” (Richard Sterling and Joseph Lim, Gastroenterology, Vol. 143 (6), 2012)

Editors and Affiliations

  • Bon Secours Health System, Liver Institute of Virginia, Newport News, USA

    Mitchell L. Shiffman

About the editor

Mitchell L.  Shiffman, MD
Liver Institute of Virginia, Bon Secours Health System, Richmond, VA, USA

Bibliographic Information

  • Book Title: Chronic Hepatitis C Virus

  • Book Subtitle: Advances in Treatment, Promise for the Future

  • Editors: Mitchell L. Shiffman

  • DOI: https://doi.org/10.1007/978-1-4614-1192-5

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-4614-1191-8Published: 30 November 2011

  • Softcover ISBN: 978-1-4614-5873-9Due: 24 September 2012

  • eBook ISBN: 978-1-4614-1192-5Published: 17 November 2011

  • Edition Number: 1

  • Number of Pages: XVI, 332

  • Number of Illustrations: 20 b/w illustrations, 33 illustrations in colour

  • Topics: Hepatology, Gastroenterology

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