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Endocrine FGFs and Klothos

  • Book
  • © 2012

Overview

Editors:
  1. Makoto Kuro-o

    1. Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, USA

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  • Discusses potential of FGF23 and Klotho as novel diagnostic markers and therapeutic targets for chronic kidney disease
  • Gives an overview of current knowledge on FGF19 and FGF21
  • Comprehensive in scope

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 728)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xix
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  2. The Structural Biology of the FGF19 Subfamily

    • Andrew Beenken, Moosa Mohammadi
    Pages 1-24

  3. Klotho and βKlotho

    • Makoto Kuro-o
    Pages 25-40

  4. FGF23 and Syndromes of Abnormal Renal Phosphate Handling

    • Clemens Bergwitz, Harald Jüppner
    Pages 41-64

  5. Evidence for FGF23 Involvement in a Bone-Kidney Axis Regulating Bone Mineralization and Systemic Phosphate and Vitamin D Homeostasis

    • Aline Martin, L. Darryl Quarles
    Pages 65-83

  6. FGF23, Klotho and Vitamin D Interactions:

    • M. Shawkat Razzaque
    Pages 84-91

  7. FGF23 and the Parathyroid

    • Justin Silver, Tally Naveh-Many
    Pages 92-99

  8. Regulation of Ion Channels by Secreted Klotho

    • Chou-Long Huang
    Pages 100-106

  9. FGF23 in Chronic Kidney Disease

    • Patricia Wahl, Myles Wolf
    Pages 107-125

  10. Secreted Klotho and Chronic Kidney Disease

    • Ming Chang Hu, Makoto Kuro-o, Orson W. Moe
    Pages 126-157

  11. FGF23 as a Novel Therapeutic Target

    • Takashi Shimada, Seiji Fukumoto
    Pages 158-170

  12. Physiology of FGF15/19

    • Stacey A. Jones
    Pages 171-182

  13. FGF19 and Cancer

    • Benjamin C. Lin, Luc R. Desnoyers
    Pages 183-194

  14. Understanding the Structure-Function Relationship between FGF19 and Its Mitogenic and Metabolic Activities

    • Xinle Wu, Yang Li
    Pages 195-213

  15. FGF21 as a Therapeutic Reagent

    • Yang Zhao, James D. Dunbar, Alexei Kharitonenkov
    Pages 214-228

  16. Back Matter

    Pages 229-233
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Keywords

About this book

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

Editors and Affiliations

  • Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, USA

    Makoto Kuro-o

About the editor

MAKOTO KURO-O is an Associate Professor in the Pathology Department at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern). He also has an appointment to the Pak Center for Mineral Metabolism and the Simmons Comprehensive Cancer Center in UT Southwestern. He received his MD and PhD from the University of Tokyo, Japan. His major research interests include molecular mechanisms of aging and age-related diseases with special reference to chronic kidney disease. He is a member of the American Society of Nephrology (ASN).

Bibliographic Information

  • Book Title: Endocrine FGFs and Klothos

  • Editors: Makoto Kuro-o

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-0887-1

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2012

  • Hardcover ISBN: 978-1-4614-0886-4Published: 11 January 2012

  • eBook ISBN: 978-1-4614-0887-1Published: 06 March 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XX, 210

  • Number of Illustrations: 37 b/w illustrations, 1 illustrations in colour

  • Topics: Cell Biology, Gene Expression

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