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Advances in Experimental Medicine and Biology

Endocrine FGFs and Klothos

Editors: Kuro-o, Makoto (Ed.)

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  • Discusses potential of FGF23 and Klotho as novel diagnostic markers and therapeutic targets for chronic kidney disease
  • Gives an overview of current knowledge on FGF19 and FGF21
  • Comprehensive in scope
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About this book

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

About the authors

MAKOTO KURO-O is an Associate Professor in the Pathology Department at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern). He also has an appointment to the Pak Center for Mineral Metabolism and the Simmons Comprehensive Cancer Center in UT Southwestern. He received his MD and PhD from the University of Tokyo, Japan. His major research interests include molecular mechanisms of aging and age-related diseases with special reference to chronic kidney disease. He is a member of the American Society of Nephrology (ASN).

Table of contents (14 chapters)

Table of contents (14 chapters)

Buy this book

eBook $189.00
price for USA in USD
  • ISBN 978-1-4614-0887-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4614-0886-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Online orders shipping within 2-3 days.
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Bibliographic Information

Bibliographic Information
Book Title
Endocrine FGFs and Klothos
Editors
  • Makoto Kuro-o
Series Title
Advances in Experimental Medicine and Biology
Series Volume
728
Copyright
2012
Publisher
Springer-Verlag New York
Copyright Holder
Landes Bioscience and Springer Science+Business Media, LLC
eBook ISBN
978-1-4614-0887-1
DOI
10.1007/978-1-4614-0887-1
Hardcover ISBN
978-1-4614-0886-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XX, 210
Number of Illustrations
37 b/w illustrations, 1 illustrations in colour
Topics

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