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Nonanticoagulant Actions of Glycosaminoglycans

Editors: Casu, B., Harenberg, Job (Eds.)

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About this book

Prophylaxis and treatment of thromboembolism have made one of the major impacts in medicine. Heparin has widely been used as the most effective drug during the last 50 years. However, its potential side effects have led to the search for equally effective but safer alternatives. At present, the low-molecular-weight heparins are the most promising steps in this direction. Considerable interest has been generated at the same time in exploring other gly­ cosaminoglycans of the nonheparin type for therapeutic use. The existence of these com­ pounds has been known for a long time and substantial information has been gathered on glycosaminoglycans such as heparinsulfate, dermatansulfate, and chondroitinsulfate. Many of these substances are derived from animal or plant sources, and some of them have now been synthesized. The aim of the Fourth Symposium on Glycosaminoglycan Research at Villa Vigoni in Loveno at Lake Comolltaly was to summarize the considerable new information in this field. The articles of the present volume are mainly based on a German-Italian collaboration supported by the Vigoni Program. The selected articles describe many different, nonheparin glycosaminoglycans, some of them already in clinical trials as antithrombotic agents. In particular, the interaction of glycosaminoglycans with some cellular elements of blood, especially leukocytes and platelets, are discussed. New methods for their identification and assays are described and considerable emphasis is placed on the pharmacokinetic aspects of these new compounds. Particularly, some nonanticoagulant activities of the glycosamino­ glycans are discussed in detail.

Table of contents (21 chapters)

Table of contents (21 chapters)
  • Inequivalence of Glycosaminoglycans Using High-Performance Size Exclusion Chromatography, Polyacrylamide Gel Electrophoresis and High-Performance Capillary Electrophoresis

    Pages 1-14

    Malsch, Reinhard (et al.)

  • New NMR Spectroscopic Approaches for Structural Analysis of Glycosaminoglycans

    Pages 15-25

    Torri, Giangiacomo

  • Application of Mass Spectrometry to the Analysis of Natural and Synthetic Sulfated Oligosaccharides

    Pages 27-46

    Silvestro, Luigi (et al.)

  • Monoclonal Antibody Directed Against Heparin and Heparin-Fractions

    Pages 47-58

    Huhle, Günter (et al.)

  • Simulation of Glycosaminoglycan Structures by Chemical Modifications of E. Coli Polysaccharides K5 and K4

    Pages 59-64

    Naggi, Annamaria

Buy this book

eBook $59.99
price for USA in USD
  • ISBN 978-1-4613-0371-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $79.99
price for USA in USD
  • ISBN 978-1-4613-8021-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Nonanticoagulant Actions of Glycosaminoglycans
Editors
  • B. Casu
  • Job Harenberg
Copyright
1996
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4613-0371-8
DOI
10.1007/978-1-4613-0371-8
Softcover ISBN
978-1-4613-8021-4
Edition Number
1
Number of Pages
288
Topics

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