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Advances in Experimental Medicine and Biology

Inhibitors to Coagulation Factors

Editors: Aledort, L.M., Hoyer, L.W., Lusher, J.M., Reisner, H.M., White II, G.C. (Eds.)

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About this book

"For the blood is the life . . . . "(Deut. 12 :23) " . . . because the blood, in its value as life, makes atonement" (Lev. 17: 11) HemoPhilia is a rare disease, severe hemophilia rarer still, yet the written history of hemophilia extends back over a millennium and a half. In the ancient Middle East, blood and life were coupled. Blood was the primary substance necessary for life, given to God in sacrifice and forbidden as a food to mortals by Levitical law. Blood was essential for rites of purification and consecration. But the flow of blood during menstruation or parturition rendered a woman unclean. The circumcision of a male child required 33 days of "blood purification" by the mother. ' Circumcision, the visible reminder of the covenant of Abraham lijith Yahweh, was required of newborn Jewish males. It "connote(d) suitability for participation in what God is doing. "2 Hence, free and uncontrolled bleeding of the male child during circumcision, during the ratification of God's covenant, would be noted with awe and concern by those of the Jewish faith. It should not be surprising that the first genetic counseling offered to families with hemophilia is found in the Babylonian Talmud (compilation of Jewish law dated to about the third century AD) and concerns the necessity for circumcision in families with what we would now call hemophilia.

Table of contents (22 chapters)

Table of contents (22 chapters)
  • Structure and function of Factor VIII

    Pages 3-17

    Lollar, Pete

  • Molecular etiology of factor VIII deficiency in hemophilia A

    Pages 19-34

    Antonarakis, Stylianos E. (et al.)

  • The incidence of factor VIII inhibitors in patients with severe hemophilia A

    Pages 35-45

    Hoyer, Leon W.

  • Epitope specificity and functional characterization of factor VIII inhibitors

    Pages 47-63

    Scandella, Dorothea (et al.)

  • Immunogenetics of the human immune response to factor VIII

    Pages 65-78

    Reisner, Howard M. (et al.)

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-1-4613-0331-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $79.99
price for USA in USD
  • ISBN 978-1-4613-8001-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Inhibitors to Coagulation Factors
Editors
  • Louis M. Aledort
  • Leon W. Hoyer
  • Jeanne M. Lusher
  • Howard M. Reisner
  • Gilbert C. White II
Series Title
Advances in Experimental Medicine and Biology
Series Volume
386
Copyright
1995
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4613-0331-2
DOI
10.1007/978-1-4613-0331-2
Softcover ISBN
978-1-4613-8001-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
324
Topics