Resolving the Antibiotic Paradox

1. Front Matter

   Pages i-x

   PDF

2. Antibiotic Resistance

   • Didier Mazel, Julian Davies

   Pages 1-6

3. Clinical Impact of Antibiotic Resistance

   • Stephen A. Lerner

   Pages 7-15

4. Reversing Tetracycline Resistance

   • Stuart B. Levy, Mark Nelson

   Pages 17-25

5. Aminoglycoside Antibiotics

   • Gerard D. Wright, Albert M. Berghuis, Shahriar Mobashery

   Pages 27-69

6. How β-Lactamases Have Driven Pharmaceutical Drug Discovery

   • Karen Bush, Shahriar Mobashery

   Pages 71-98

7. Antifolate Resistance Mechanisms from Bacteria to Cancer Cells with Emphasis on Parasites

   • Marc Ouellette, Éric Leblanc, Christoph Kündig, Barbara Papadopoulou

   Pages 99-113

8. Resistance to Antitubercular Drugs

   • Luiz A. Basso, John S. Blanchard

   Pages 115-144

9. Structure and Function of Multidrug Transporters

   • Hendrik W. van Veen, Wil N. Konings

   Pages 145-158

10. Metalloid Resistance Mechanisms

    • Rita Mukhopadhyay, Jiaxin Li, Hiranmoy Bhattacharjee, Barry P. Rosen

    Pages 159-181

11. The Impact of Bacterial Genomics on Antibacterial Discovery

    • David J. C. Knowles, Frank King

    Pages 183-195

12. Peptidoglycan Biosynthesis

    • Kenny K. Wong, David L. Pompliano

    Pages 197-217

13. Design, Synthesis, and Evaluation of Novel Oxazolidinone Antibacterial Agents Active Against Multidrug-Resistant Bacteria

    • Michael R. Barbachyn, Steven J. Brickner, Robert C. Gadwood, Stuart A. Garmon, Kevin C. Grega, Douglas K. Hutchinson et al.

    Pages 219-238

14. Concept, Design, and Preclinical Evaluation of Quinolonyl Lactam Antibacterials

    • Paul M. Hershberger, Thomas P. Demuth Jr.

    Pages 239-267

15. Bacterial Two-Component Signalling as a Therapeutic Target in Drug Design

    • John M. Domagala, Diane Alessi, Maxwell Cummings, Stephen Gracheck, Liren Huang, Michael Huband et al.

    Pages 269-286

16. Back Matter

    Pages 287-293

    PDF

Antibiotic resistance, once a term appreciated only by microbiologists, has become a common topic in the popular press. Stuart Levy, one of the contributors to this collection, bears some of the responsibility for increasing public awareness with the publication of his book "The Antibiotic Paradox" in 1992: Misuse of antibiotics resulting in increased bacterial resistance had previously been recognized in the infectious disease community. However, Dr. Levy's eloquent public warning about the shrinking efficacy of our antibi­ otic armamentarium served to alert the lay person to the potential consequences of this de­ mise in useful therapy. Because of the proliferation of diverse antibiotic classes with increasing potency and broader activity spectra, it had been assumed that any ordinary bacterial infection could be eradicated with the proper selection of drug. However, it has become evident that we are surrounded by resistant bacteria, many of which were introduced unwittingly into our en­ vironment through the unnecessary use of antibiotics. When it became evident that a number of people were returning for multiple visits to their family physicians for persist­ ent ear infections or non-responsive bronchitis, questions were raised about the antibiotic treatments that were being prescribed. Bacteria resistant to common antibiotic regimens were being isolated more frequently, often as organisms classified as "multi-resistant" with decreased susceptibilities to two or more structural classes of agents. Nosocomial spread of these resistances was aided by the transmission of plasmid-mediated resistance factors between species.

• antibiotics
• bacteria
• infectious
• infectious disease
• infectious diseases

• Wayne State University, Detroit, USA

  Barry P. Rosen, Shahriar Mobashery

Policies and ethics