Metals and Genetics

1. Front Matter

   Pages i-xi

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2. Eulogy for Karen Wetterhahn

   • William A. Suk

   Pages 1-3

3. Metalloregulation of Soft Metal Resistance Pumps

   • Chun Xu, Barry P. Rosen

   Pages 5-19

4. Clastogenic Effects and Influence of Inorganic Arsenic on DNA-Repair in Mammalian Systems

   • R. Nilsson, A. T. Natarajan, A. Hartwig, F. Dulout, M. E. De la Rosa, M. Vahter

   Pages 21-40

5. Groundwater Arsenic Contamination and Sufferings of People in West Bengal, India and Bangladesh

   • Badal K. Mandai, Bhaja K. Biswas, Ratan K. Dhar, Tarit Roy Chowdhury, Gautam Samanta, Gautam K. Basu et al.

   Pages 41-65

6. The Nature and Extent of Arsenic-Affected Drinking Water in Bangladesh

   • Seth H. Frisbie, Donald M. Maynard, Bilqis A. Hoque

   Pages 67-85

7. Chromium Biomonitoring

   • Andreas Kortenkamp

   Pages 87-100

8. Chelate Sensor Method for Mercury

   • Horacio Kido, Ferenc Szurdoki, Mae S. Gustin, Bruce D. Hammock

   Pages 101-116

9. Copper Transport and Ceruloplasmin During Lactation and Pregnancy

   • Maria C. Linder, Stephanie Donley, David Dominguez, Lisa Wooten, Farrokh Mehrbod, Philip Cerveza et al.

   Pages 117-129

10. CAP43

    • Konstantin Salnikow, Daoji Zhou, Tomasz Kluz, Cheng Wang, Max Costa

    Pages 131-144

11. Zinc and Metallothionein in Mammalian Cell Cycle Regulation

    • Detmar Beyersmann, Carsten Schmidt

    Pages 145-158

12. Effect of Metal Compounds on the Function of Zinc Finger Proteins Involved in DNA Repair

    • Andrea Hartwig, Leon H. F. Mullenders, Monika Asmuß, Maike Benters, Ines Krüger

    Pages 159-169

13. Chromium(III) as a Male Preconception Carcinogen in Mice

    • Lucy M. Anderson, Marek A. Sipowicz, Wei Yu, Bhalchandra A. Diwan, Lisa Birely, Diana C. Haines et al.

    Pages 171-182

14. DNA Cleavage vs. Cross-Linking Using Nickel Peptides

    • Robyn P. Hickerson, Victor Duarte, J. David Van Horn, Ronelito J. Perez, James G. Muller, Steven E. Rokita et al.

    Pages 183-196

15. Copper-Dependent DNA Scission

    • David S. Sigman, Lisa Milne, Yue Xu, James Gallagher, David M. Perrin, Clark Pan

    Pages 197-208

16. Modulation of Glucocorticoid Signaling and Leukocyte Activation by Transition Metals

    • J. Koropatnick, J. M. De Moor, O. M. Collins

    Pages 209-220

17. Reactions of Copper-Zinc Superoxide Dismutases with Hydrogen Peroxide

    • Joan Selverstone Valentine

    Pages 221-228

18. Yeast Mitochondrial Iron Metabolism and the Pathophysiology of Friedreich’s Ataxia

    • Jerry Kaplan, Derek Radisky, Michael Babcock

    Pages 229-236

19. Getting Copper into Mitochondria

    • D. M. Glerum, J. Beers, A. Tzagoloff, F. Punter, D. Adams

    Pages 237-254

20. The Copper-Transporting ATpase Defective in Wilson Disease

    • Diane W. Cox, John R. Forbes, Manoj S. Nanji

    Pages 255-264

During the past few years, major scientific discoveries have greatly contributed to our understanding of the relationship between metals and genetics. The fields which have contrib­ uted to this area range from Clinical Medicine and Genetics to Biochemistry and Chemistry. The aim of this book is to bring together investigators from these diverse fields to reflect on the broad implications of direct and indirect interactions of metals and genetic components. The volume begins with a tribute to the late Karen Wetterhahn, an outstanding scien­ tist in the field, who will be sadly missed by her friends and colleagues because of her un­ timely death. The book has 28 chapters contributed by scientists who are internationally known for their expertise and outstanding research. The subject matters are divided into five major sections. The first section discusses genetic response to environmental expo­ sure to metals. Potentially devastating health crises have been reported in recent years from several parts of the world, which stem from environmental exposure to metals. In this section, authors report their findings on the effects and influence of metals in gene ex­ pression and their consequences to human health. The section on metal carcinogenesis and metal caused DNA damage, presents the latest advances in our knowledge of the molecu­ lar mechanisms of metal-induced mutagenesis and carcinogenesis. This topic is at the very heart of our understanding of how cancer may be caused by various metals.

• DNA
• biochemistry
• gene expression
• genes
• genetics
• molecular mechanisms
• pathophysiology
• physiology
• regulation

• The Hospital for Sick Children, The University of Toronto, Toronto, Canada

  Bibudhendra Sarkar

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