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Advances in Experimental Medicine and Biology

Elastic Filaments of the Cell

Editors: Granzier, H.L., Pollack, Gerald H. (Eds.)

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About this book

Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.

Table of contents (24 chapters)

Table of contents (24 chapters)
  • Connecting Filaments: A Historical Prospective

    Pages 1-23

    Trombitás, Károly

  • Connectin: From Regular to Giant Sizes of Sarcomeres

    Pages 25-33

    Maruyama, Koscak (et al.)

  • Molecular Tools for the Study of Titin’s Differential Expression

    Pages 35-52

    Centner, Thomas (et al.)

  • Sequence and Mechanical Implications of Titin’s PEVK Region

    Pages 53-66

    Greaser, Marion L. (et al.)

  • Probing the Functional Roles of Titin Ligands in Cardiac Myofibril Assembly and Maintenance

    Pages 67-88

    McElhinny, Abigail S. (et al.)

Buy this book

eBook $84.99
price for USA in USD
  • ISBN 978-1-4615-4267-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.99
price for USA in USD
  • ISBN 978-1-4613-6916-5
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Elastic Filaments of the Cell
Editors
  • H.L. Granzier
  • Gerald H. Pollack
Series Title
Advances in Experimental Medicine and Biology
Series Volume
481
Copyright
2000
Publisher
Springer US
Copyright Holder
Kluwer Academic/Plenum Publishers, New York
eBook ISBN
978-1-4615-4267-4
DOI
10.1007/978-1-4615-4267-4
Softcover ISBN
978-1-4613-6916-5
Series ISSN
0065-2598
Edition Number
1
Number of Pages
IX, 425
Topics

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