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Chemical Carcinogenesis 2

Modulating Factors

Editors: Columbano, A., Feo, F., Pani, P., Pascale, R. (Eds.)

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About this book

"chemical carcinogenesis" is the general title of the series of international meetings which are held, biannually, in sardinia (Italy) since 1981. Despite the generality of the title, the main effort of the scientific Committee has been to pursue a coherent line around one of the most distinguishing features of carcinogenesis: the "multifasic" development of the process. Given that many chemical compounds are known to cause "experimental cancer", many questions still remain unresolved or are given too simplistic answers. The very first question concerning the interaction between the chemical carcinogen and the molecular target in the cell is a debatable one despite the overwhelming literature in this field. It is certain that chemical carcinogens are toxic to cells and cause DNA damage: however it is still an open question as to how to relate these changes to the different stages of carcinogenesis including initiation. We have not to forget that 1/3 to 2/3 of the average life time of a given species elapses between the experimental administration of the carcinogen and the appearance of "cancer". The experimental manipulation of carcinogenesis through the use of "adequate biological models" has not simplified the problems about cancer, but it has led us to face the complexity of otherwise elementary biological properties, cell proliferation and differentiation. The understanding of this biological complexity is not just theoretical, but it may give us those adequate conceptual tools to approach "cancer" also from a medical point of view.

Table of contents (62 chapters)

Table of contents (62 chapters)
  • Nuclear Oncogenes as Transcription Factors

    Pages 3-9

    Sassone-Corsi, P. (et al.)

  • Control of Hepatocyte Growth by Positive and Negative Growth Regulators and Mitogenic Triggers: Implications for Hepatic Neoplasia

    Pages 11-17

    Michalopoulos, G. K.

  • Cell Cycle Dependent Regulation of Poly(ADP-Ribose) Polymerase Gene Expression

    Pages 19-27

    Prati, A. Carcereri (et al.)

  • Different Expression of Cell Cycle Related Genes during Liver Regeneration and Liver Hyperplasia

    Pages 29-38

    Coni, P. (et al.)

  • S-Adenosylmethionine Content, DNA Methylation and Gene Expression in Regenerating Liver

    Pages 39-47

    Simile, M. M. (et al.)

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-1-4615-3694-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $79.99
price for USA in USD
  • ISBN 978-1-4613-6642-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Chemical Carcinogenesis 2
Book Subtitle
Modulating Factors
Editors
  • A. Columbano
  • Francesco Feo
  • P. Pani
  • R. Pascale
Copyright
1991
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-3694-9
DOI
10.1007/978-1-4615-3694-9
Softcover ISBN
978-1-4613-6642-3
Edition Number
1
Number of Pages
XII, 653
Topics