Innovations in Antiviral Development and the Detection of Virus Infections
Editors: Block, T., Crowell, R., Dennison, M., Jungkind, D.L., Walsh, L.R. (Eds.)
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- About this book
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THE ERA OF ANTIVIRALS Introduction Although there are more than one hundred medically useful antibiotics and fungicides, there are only seven compounds licensed for use as antiviral agents, in the USA. Some of these (acyclovir and ganciclovir) are actually derivatives of each other, making the number of new discoveries even smaller. Moreover, most of these agents are of only limited therapeutic value and have substantial toxicity. It has been more than 100 years ago since Pasteur studied rabies virus (2) and Rous (4) showed that a small filterable agent (not bacteria) caused disease (sarcoma) in chickens. It was nearly 100 years ago that yellow fever virus, the first recognized human pathogenic virus, was unambiguously associated with disease (3). Enteroviruses were cultured for the first time nearly 50 years ago (1). Why then has effective chemotherapy against viruses lagged behind that of other microorganisms? Viruses are often difficult to grow and image. However, with the dynamic advances in molecular biology and increased sophistication in tissue culture, the field of virology has blossomed and resulted in improved methods for detection of virus infection. The use of viruses as models of gene regulation and replication has also resulted in a massive accumulation of information.
- Table of contents (21 chapters)
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Studies of Reovirus Pathogenesis Reveal Potential Sites for Antiviral Intervention
Pages 1-14
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Drugs as Molecular Tools
Pages 15-24
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Genetically Engineered Bacteria to Identify and Produce Anti-Viral Agents
Pages 25-40
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Antiviral Agents from Novel Marine and Terrestrial Sources
Pages 41-60
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Virus Receptors: The Achilles’ Heel of Human Rhinoviruses
Pages 61-70
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Table of contents (21 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Innovations in Antiviral Development and the Detection of Virus Infections
- Editors
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- Timothy Block
- Richard Crowell
- Mark Dennison
- Donald L. Jungkind
- Lori R. Walsh
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- 312
- Copyright
- 1992
- Publisher
- Springer US
- Copyright Holder
- Springer Science+Business Media New York
- eBook ISBN
- 978-1-4615-3462-4
- DOI
- 10.1007/978-1-4615-3462-4
- Softcover ISBN
- 978-1-4613-6533-4
- Series ISSN
- 0065-2598
- Edition Number
- 1
- Number of Pages
- XVII, 218
- Topics
