Advances in Experimental Medicine and Biology

Current Directions in Insulin-Like Growth Factor Research

Editors: LeRoith, Derek, Raizada, Mohan K. (Eds.)

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About this book

The study of the insulin-like growth factor (IGF) family has become an exciting area of investigation. Initially, this family consisted of ligands (insulin, IGF-I and IGF-m and receptors (the insulin receptor, the type I or IGF-I receptor and the type II or IGF-IYM-6-P receptor). Subsequently, it was discovered that six specific binding proteips (lGFBPs 1-6) playa major role in the actions of this growth factor family. In addition, there are now more potential receptors when one considers the possible roles of the insulin-receptor related receptor (IRR) and hybrid receptor dimers composed of insulin and IGF-I receptor (half-receptors). Another important aspect of this area of research is the realization that the IGFs are not only essential for normal growth and development but, in addition play an important role in the normal specialized function(s) of all tissues of the body, including the nervous system, skeleton, reproductive system, kidney, and the immune system, to name but a few. The development of recombi!tant human IGF-I for clinical testing has been a major breakthrough for investigators. Potential uses include wound healing, reversal of catabolic states, diabetes, bone remodeling, recovery from acute renal failure and many others. will determine both its use and its potential hazards.

Table of contents (38 chapters)

  • Structure, Expression, and Regulation of the IGF-I Gene

    Adamo, Martin L. (et al.)

    Pages 1-11

  • Differential Regulation of IGF-I Leader Exon Transcription

    Pell, Jennifer M. (et al.)

    Pages 13-23

  • Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin Pharmacokinetics

    Slieker, Lawrence J. (et al.)

    Pages 25-32

  • Analysis of the Interaction of IGF-I Analogs with the IGF-I Receptor and IGF Binding Proteins

    Cascieri, Margaret A. (et al.)

    Pages 33-40

  • Synthesis and Characterization of IGF-II Analogs: Applications in the Evaluation of IGF Receptor Function and IGF-Independent Actions of IGFBPS

    Oh, Youngman (et al.)

    Pages 41-54

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-1-4615-2988-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $79.99
price for USA in USD
  • ISBN 978-1-4613-6301-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Current Directions in Insulin-Like Growth Factor Research
Editors
  • Derek LeRoith
  • Mohan K. Raizada
Series Title
Advances in Experimental Medicine and Biology
Series Volume
343
Copyright
1993
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4615-2988-0
DOI
10.1007/978-1-4615-2988-0
Softcover ISBN
978-1-4613-6301-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XI, 417
Topics