Frontiers in Cerebral Vascular Biology

1. Front Matter

   Pages i-x

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2. Glucose Transport

   1. Front Matter

      Pages 1-1

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   2. Developmental Expression of Glucose Transporters, Glut1 and Glut3, in Postnatal Rat Brain

      • Susan J. Vannucci, Lisa B. Willing, Robert C. Vannucci

      Pages 3-7

   3. Alterations in Brain Glucose Transporter Proteins, Glut1 and Glut3, in Streptozotocin Diabetic Rats

      • Fran Maher, Ian A. Simpson, Susan J. Vannucci

      Pages 9-12

   4. Glucose Transporter (Glut1) Expression by Canine Brain Microvessel Endothelial Cells in Culture: An Immunocytochemical Study

      • Jay M. Hemmila, Lester R. Drewes

      Pages 13-18

   5. Application of Novel PCR Strategies to Amplify and Sequence Glucose Transporters in Canine Brain

      • Nancy D. Borson, Wilmar L. Salo, Lester R. Drewes

      Pages 19-24

   6. Estimation of Unidirectional Clearances of FDG and Glucose Across the Blood-Brain Barrier in Man

      • Steen Hasselbalch, Gitte Moos Knudsen, Johannes Jakobsen, Søren Holm, Olaf B. Paulson

      Pages 25-27

   7. Rat Brain Glucose Concentration and Transport Kinetics Determined with 13C Nuclear Magnetic Resonance Spectroscopy

      • Graeme F. Mason, Kevin L. Behar, Margaret A. Martin, Robert G. Shulman

      Pages 29-34

   8. Non-Invasive Measurements of the Cerebral Steady-State Glucose Concentration and Transport in Humans by 13C Nuclear Magnetic Resonance

      • Rolf Gruetter, Edward J. Novotny, Susan D. Boulware, Douglas L. Rothman, Graeme F. Mason, Gerald I. Shulman et al.

      Pages 35-40

3. Electrolyte Transport

   1. Front Matter

      Pages 41-41

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   2. Potassium Transport at the Blood-Brain and Blood-CSF Barriers

      • Richard F. Keep, Jianming Xiang, A. Lorris Betz

      Pages 43-54

   3. Expression of Na, K-ATPase at the Blood-Brain Interface

      • Berislav V. Zlokovic, Liang Wang, Jasmina B. Mackic, Asma J. Saraj, J. Gordon McComb, Alicia McDonough

      Pages 55-60

   4. Effects of Protein Kinase C Agonists on Na, K-ATPase Activity in Rat Brain Microvessels

      • Hiroo Johshita, Takao Asano, Tohru Matsui, Tohru Koide

      Pages 61-64

   5. Brain Volume Regulation During Development: The Role of Blood-Brain Barrier Potassium Transport

      • Richard F. Keep, Jianming Xiang, Steven R. Ennis, Mary E. Beer, A. Lorris Betz

      Pages 65-69

   6. The Transendothelial DC Potential of Rat Blood-Brain Barrier Vessels in Situ

      • Patricia A. Revest, Hazel C. Jones, N. Joan Abbott

      Pages 71-74

   7. Phosphate Transport in Capillaries of the Blood-Brain Barrier

      • Richard Béliveau, Lise Dallaire, Sylvie Giroux

      Pages 75-80

4. Drug and Amino Acid Transport

   1. Front Matter

      Pages 81-81

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   2. Drug Delivery to Brain and the Role of Carrier-Mediated Transport

      • Quentin R. Smith

      Pages 83-93

   3. Vasopressin Modulates the Blood-Brain Transfer of Amino Acids-Studies with [11C]Methionine in Dogs

      • Peter Brust, Dean F. Wong, Albert Gjedde, Armin Ermisch

      Pages 95-100

   4. Amino Acid Transport at the Blood-Nerve Barrier of the Rat Peripheral Nerve

      • Kishena C. Wadhwani, Quentin R. Smith, Stanley I. Rapoport

      Pages 101-106

During the past three decades, the cerebral vasculature and its role in blood-brain transport has been an increasingly active area of investigation and learning, particularly from an anatomical and physiological point of view. However, much less is known at the molecular and cellular level about the blood-brain barrier especially regarding the macromolecules responsible for transport, the roles played by vascular wall components (endothelial cell, pericyte, smooth muscle, basement membrane), and the mechanisms regulating brain vascular-specific protein expression and their molecular alterations during development and disease. Fundamental questions still unanswered include: What are the molecular constituents of brain endothelial cell tight junctions? What are the membrane proteins responsible for transport of specific substrates? What are the molecular signals that cause glucose transporter gene expression to be 20 to 100 times greater in brain endothelial cells in vivo than in vitro? What roles do pericytes, smooth muscle cells and basement membrane have in establishing or maintaining blood-brain transport characteristics? Are brain vascular transport systems responsible for edema following injury? Are transporter systems regulated via receptor-mediated events? Do hormones or neuromodulators regulate transporter expression? What is the molecular mechanism by which plasma proteins enter the extravascular space? Are transporters asymmetrically distributed between the luminal and abluminal endothelial cell membranes? Can prodrugs or pharmacologic agents be designed as substrate analogs and be delivered to the central nervous system via existing transporters or receptors? Can new and beneficial transporters be introduced into the brain vasculature?

• Nervous System
• biology
• brain
• central nervous system
• development
• gene expression
• muscle
• receptor
• research
• system

• University of Minnesota, Duluth, USA

  Lester R. Drewes

• The University of Michigan, Ann Arbor, USA

  A. Lorris Betz

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