Advances in Experimental Medicine and Biology

Frontiers in Cerebral Vascular Biology

Transport and Its Regulation

Editors: Drewes, Lester R., Betz, A.Lorris (Eds.)

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About this book

During the past three decades, the cerebral vasculature and its role in blood-brain transport has been an increasingly active area of investigation and learning, particularly from an anatomical and physiological point of view. However, much less is known at the molecular and cellular level about the blood-brain barrier especially regarding the macromolecules responsible for transport, the roles played by vascular wall components (endothelial cell, pericyte, smooth muscle, basement membrane), and the mechanisms regulating brain vascular-specific protein expression and their molecular alterations during development and disease. Fundamental questions still unanswered include: What are the molecular constituents of brain endothelial cell tight junctions? What are the membrane proteins responsible for transport of specific substrates? What are the molecular signals that cause glucose transporter gene expression to be 20 to 100 times greater in brain endothelial cells in vivo than in vitro? What roles do pericytes, smooth muscle cells and basement membrane have in establishing or maintaining blood-brain transport characteristics? Are brain vascular transport systems responsible for edema following injury? Are transporter systems regulated via receptor-mediated events? Do hormones or neuromodulators regulate transporter expression? What is the molecular mechanism by which plasma proteins enter the extravascular space? Are transporters asymmetrically distributed between the luminal and abluminal endothelial cell membranes? Can prodrugs or pharmacologic agents be designed as substrate analogs and be delivered to the central nervous system via existing transporters or receptors? Can new and beneficial transporters be introduced into the brain vasculature?

Table of contents (44 chapters)

Table of contents (44 chapters)
  • Developmental Expression of Glucose Transporters, Glut1 and Glut3, in Postnatal Rat Brain

    Pages 3-7

    Vannucci, Susan J. (et al.)

  • Alterations in Brain Glucose Transporter Proteins, Glut1 and Glut3, in Streptozotocin Diabetic Rats

    Pages 9-12

    Maher, Fran (et al.)

  • Glucose Transporter (Glut1) Expression by Canine Brain Microvessel Endothelial Cells in Culture: An Immunocytochemical Study

    Pages 13-18

    Hemmila, Jay M. (et al.)

  • Application of Novel PCR Strategies to Amplify and Sequence Glucose Transporters in Canine Brain

    Pages 19-24

    Borson, Nancy D. (et al.)

  • Estimation of Unidirectional Clearances of FDG and Glucose Across the Blood-Brain Barrier in Man

    Pages 25-27

    Hasselbalch, Steen (et al.)

Buy this book

eBook $59.99
price for USA in USD
  • ISBN 978-1-4615-2920-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Softcover $79.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Frontiers in Cerebral Vascular Biology
Book Subtitle
Transport and Its Regulation
Editors
  • Lester R. Drewes
  • A.Lorris Betz
Series Title
Advances in Experimental Medicine and Biology
Series Volume
331
Copyright
1993
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-2920-0
DOI
10.1007/978-1-4615-2920-0
Softcover ISBN
978-1-4613-6267-8
Series ISSN
0065-2598
Edition Number
1
Number of Pages
306
Number of Illustrations
76 b/w illustrations
Topics