Translational Regulation of Gene Expression 2

1. Front Matter

   Pages i-xxiv

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2. A Two-Ribosome Model for Attenuation

   • G. Wesley Hatfield

   Pages 1-22

3. Regulation of Ribosomal Protein mRNA Translation in Bacteria

   • Claude Portier, Marianne Grunberg-Manago

   Pages 23-47

4. Role of Elongation Factors in Steering the Ribosomal Elongation Cycle

   • Knud H. Nierhaus, Francisco Triana

   Pages 49-68

5. Genetics of Translation Initiation Factors in Saccharomyces cerevisiae

   • Lan Feng, Thomas F. Donahue

   Pages 69-86

6. Regulation of GCN4 Expression in Yeast

   • Alan G. Hinnebusch, Ronald C. Wek, Thomas E. Dever, A. Mark Cigan, Lan Feng, Thomas F. Donahue

   Pages 87-115

7. Co- and Posttranslational Processes and Mitochondrial Import of Yeast Cytochrome c

   • Fred Sherman, Richard P. Moerschell, Susumu Tsunasawa, Rolf Sternglanz, Mark E. Dumont

   Pages 117-141

8. eIF-4E Phosphorylation and the Regulation of Protein Synthesis

   • Robert M. Frederickson, Nahum Sonenberg

   Pages 143-162

9. Interferon-Induced and Double-Stranded RNA-Activated Proteins as Key Enzymes Regulating Protein Synthesis

   • Ara G. Hovanessian

   Pages 163-185

10. Translational Regulation by Vaccinia Virus

    • Rostom Bablanian

    Pages 187-202

11. Translation Control by Adenovirus Virus-Associated RNA I

    • Bayar Thimmapaya, Ghanashyam D. Ghadge, Prithi Rajan, Sathyamangalam Swaminathan

    Pages 203-225

12. Translational Regulation in Adenovirus-Infected Cells

    • Robert J. Schneider, Yan Zhang

    Pages 227-250

13. Concerted Gene Expressions in Elicited Fibroin Synthesis

    • G. C. Candelas, G. Arroyo, C. Carrasco, E. Carrasquillo, A. Plazaola, M. Irizarry

    Pages 251-264

14. Translational Control in the Circadian Regulation of Luminescence in the Unicellular Dinoflagellate Gonyaulax polyedra

    • Steven Sczekan, Dong-Hee Lee, Dieter Techel, Maria Mittag, J. Woodland Hastings

    Pages 265-277

15. Autoregulation of the Heat-Shock Response

    • Susan Lindquist

    Pages 279-320

16. Repressor-Mediated Translational Control

    • William E. Walden

    Pages 321-334

17. Control of Ribosomal Protein Synthesis in Eukaryotic Cells

    • Roger L. Kaspar, David R. Morris, Michael W. White

    Pages 335-348

18. Translational Regulation in Reticulocytes

    • Jane-Jane Chen

    Pages 349-372

19. Regulation of Reticulocyte eIF-2α Kinases by Phosphorylation

    • Gisela Kramer, Wieslaw Kudlicki, Boyd Hardesty

    Pages 373-390

20. Initiation Mechanisms Used in the Translation of Bicistronic mRNAs

    • William C. Merrick, Donald D. Anthony

    Pages 391-403

This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987. It is not a revision of the earlier book but, rather, an extension of that volume witl, special emphasis on mecha­ nIsm. As the reader will discover, there is enormous diversity in the systems employing genes for translational regulation in order to regulate the appearance of the final product-the protein. Thus, we find that important proteins such as protooncogenes, growth factors, stress proteins, cytokines, lymphokines, iron­ storage and iron-uptake proteins, and a panorama of prokaryotic proteins, as well as eukaryotic viral proteins, are translationally regulated. Since for some gene products the degree of control is greater by a few orders of magnitude than their transcription, we can state that for these genes, at least, the expression is translationall y controlled. Translational regulation of gene expression in eukaryotes has emerged in the last few years as a major research field. The present book describes mechanisms of translational regulation in bacteria, yeast, and eukaryotic viruses, as well as in eukaryotic genes. In this book we try to provide in-depth coverage by including important examples from each group rather than systematically including all additional systems not described in the previous volume.

• Elongation
• Translation
• gene expression
• genes
• genetics
• ribosomal proteins
• saccharomyces cerevisiae

• Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, USA

  Joseph Ilan

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