Protease Inhibitors as Cancer Chemopreventive Agents

Editors: Kennedy, A.R., Troll, W. (Eds.)

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About this book

Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals. After it was noted that synthetic and natural inhibitors suppress two-stage carcinogenesis and breast cancer, extensive work investigating PIs as chemopreventive agents was started. PIs are unique in that they interfere with cancer development in a variety of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. The epidemiologic discovery of the importance of lentils and other seeds rich in PIs in preventing many human cancers allowed us to look at the action of PIs as chemopreventive agents, as reviewed in Chapter I (Fontham and Correa). Chapter 2 (Kennedy) discusses the role of natural PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the possible limitations of their use. In Chapter 3 (Kennedy), the transformation of C3HI lOTlh cells caused by carcinogens and promoters is shown to be suppressed by PIs. Bowman (Chapter 4) relates the discovery of inhibitors in soybeans that are distinct from the Kunitz inhibitor, and the occurrence of a similar inhibitor in peanuts and other legumes. Chapter 5 (Birk) is an overview of PIs of plant origin and their role in human nutrition.

Table of contents (18 chapters)

Table of contents (18 chapters)
  • The Epidemiologic Approach to the Study of Protease Inhibitors

    Fontham, Elizabeth (et al.)

    Pages 1-8

  • Anticarcinogenic Activity of Protease Inhibitors Overview

    Kennedy, Ann R.

    Pages 9-64

  • In Vitro Studies of Anticarcinogenic Protease Inhibitors

    Kennedy, Ann R.

    Pages 65-91

  • Discovery and Background of the Bowman-Birk Protease Inhibitors

    Bowman, Donald E.

    Pages 93-96

  • Protease Inhibitors of Plant Origin and Role of Protease Inhibitors in Human Nutrition Overview

    Birk, Yehudith

    Pages 97-106

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-1-4615-2882-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $79.99
price for USA in USD
  • ISBN 978-1-4613-6249-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Protease Inhibitors as Cancer Chemopreventive Agents
Editors
  • A.R. Kennedy
  • W. Troll
Copyright
1993
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-2882-1
DOI
10.1007/978-1-4615-2882-1
Softcover ISBN
978-1-4613-6249-4
Edition Number
1
Number of Pages
XVIII, 315
Topics