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Advances in Experimental Medicine and Biology

Mechanism of Myofilament Sliding in Muscle Contraction

Editors: Sugi, Haruo, Pollack, Gerald H. (Eds.)

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About this book

This volume presents the entire proceedings of the symposium organized by one of us (H. S. ) on November 11 to 15, 1991 at Hakone, Japan, under the title of "Mechanism of Myofllament Sliding in Muscle Contraction. " Among various kinds of energy transduction mechanisms in biological systems, the mechanism of muscle contraction has been studied most intensively and extensively over many years. Since the monumental discovery by the two Huxleys and coworkers that muscle contraction results from relative sliding between the thick and thin myofilaments, attention of muscle investigators has been focused on the question, what makes the fllaments slide past one another. In response to the above question, A. F. Huxley and Simmons put forward a contraction model in 1971, in which globular heads of myosin (cross-bridges) extending from the thick fllament first attach to actin on the thin fllament, and then change their angle of attachment to actin (power stroke) leading to force generation or myofilament sliding until they detach from the thin fllament. The rocking cross-bridge contraction model seemed to be entirely consistent with the kinetic scheme of actomyosin ATPase published by Lymn and Taylor at the same time, thus giving a strong impression to the people concerned that the muscle contraction mechanism would soon be sorted out. In his review lecture in 1974, however, A. F.

Table of contents (68 chapters)

Table of contents (68 chapters)
  • Introductory Lecture on Muscle Contraction

    Pages 1-9

    Huxley, A. F.

  • A Comparison of the Atomic Model of F-Actin with Cryo-Electron Micrographs of Actin and Decorated Actin

    Pages 15-24

    Holmes, K. C. (et al.)

  • A New Crystal Form of Tropomyosin

    Pages 25-32

    Miegel, Andrea (et al.)

  • Experiments on Rigor Crossbridge Action and Filament Sliding in Insect Flight Muscle

    Pages 33-46

    Reedy, M. K. (et al.)

  • Gross Structural Features of Myosin Head During Sliding Movement of Actin as Studied by Quick-Freeze Deep-Etch Electron Microscopy

    Pages 47-55

    Katayama, Eisaku

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4615-2872-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.99
price for USA in USD
  • ISBN 978-1-4613-6245-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mechanism of Myofilament Sliding in Muscle Contraction
Editors
  • Haruo Sugi
  • Gerald H. Pollack
Series Title
Advances in Experimental Medicine and Biology
Series Volume
332
Copyright
1993
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4615-2872-2
DOI
10.1007/978-1-4615-2872-2
Softcover ISBN
978-1-4613-6245-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XVI, 866
Topics

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