Mechanism of Myofilament Sliding in Muscle Contraction
Editors: Sugi, Haruo, Pollack, Gerald H. (Eds.)
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- About this book
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This volume presents the entire proceedings of the symposium organized by one of us (H. S. ) on November 11 to 15, 1991 at Hakone, Japan, under the title of "Mechanism of Myofllament Sliding in Muscle Contraction. " Among various kinds of energy transduction mechanisms in biological systems, the mechanism of muscle contraction has been studied most intensively and extensively over many years. Since the monumental discovery by the two Huxleys and coworkers that muscle contraction results from relative sliding between the thick and thin myofilaments, attention of muscle investigators has been focused on the question, what makes the fllaments slide past one another. In response to the above question, A. F. Huxley and Simmons put forward a contraction model in 1971, in which globular heads of myosin (cross-bridges) extending from the thick fllament first attach to actin on the thin fllament, and then change their angle of attachment to actin (power stroke) leading to force generation or myofilament sliding until they detach from the thin fllament. The rocking cross-bridge contraction model seemed to be entirely consistent with the kinetic scheme of actomyosin ATPase published by Lymn and Taylor at the same time, thus giving a strong impression to the people concerned that the muscle contraction mechanism would soon be sorted out. In his review lecture in 1974, however, A. F.
- Table of contents (68 chapters)
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Introductory Lecture on Muscle Contraction
Pages 1-9
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A Comparison of the Atomic Model of F-Actin with Cryo-Electron Micrographs of Actin and Decorated Actin
Pages 15-24
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A New Crystal Form of Tropomyosin
Pages 25-32
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Experiments on Rigor Crossbridge Action and Filament Sliding in Insect Flight Muscle
Pages 33-46
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Gross Structural Features of Myosin Head During Sliding Movement of Actin as Studied by Quick-Freeze Deep-Etch Electron Microscopy
Pages 47-55
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Table of contents (68 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Mechanism of Myofilament Sliding in Muscle Contraction
- Editors
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- Haruo Sugi
- Gerald H. Pollack
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- 332
- Copyright
- 1993
- Publisher
- Springer US
- Copyright Holder
- Plenum Press, New York
- eBook ISBN
- 978-1-4615-2872-2
- DOI
- 10.1007/978-1-4615-2872-2
- Softcover ISBN
- 978-1-4613-6245-6
- Series ISSN
- 0065-2598
- Edition Number
- 1
- Number of Pages
- XVI, 866
- Topics
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