Alcohol, Cell Membranes, and Signal Transduction in Brain

Editors: Alling, C., Diamond, I., Leslie, S.W., Sun, G.Y., Wood, W.G. (Eds.)

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About this book

Alcohol abuse and alcoholism are international problems whose costs economical­ ly, psychologically and medically have been well documented. Alcohol is a unique drug in that the effects of excessive use can have a deleterious effect on most if not all organs of the body. The brain is one of the organs most affected by excessive alcohol consumption. Effects on the brain can be seen in cognitive function, brain structure and neurochemistry. Over the past few years, there have been significant advances made in understanding how alcohol affects brain neurochemistry. This book examines four major areas, i. e. , membrane lipids, receptors and ion channels, second messengers, and gene expression, where significant advancements have been made. The book is divided into four sections based on the four major areas. In each section, data are examined that cover a range of approaches from in vitro to in vivo studies. The section on membrane lipids includes recent developments in how ethanol affects membrane cholesterol domains, polyunsaturated fatty acids, the cause and consequences of phosphatidylethanol formation, and the modulation of membrane protein function by lipid-protein interaction. The second section comprises chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol neurotoxicity and the molecular heterogeneity that may underlie differences in alcohol sensitivity as well as chapters on GABA-gated chloride flux, and calcium channels.

Table of contents (28 chapters)

Table of contents (28 chapters)
  • Molecular Mechanisms of Ethanol and Anesthetic Actions: Lipid- and Protein-Based Theories

    Stubbs, Christopher D. (et al.)

    Pages 1-11

  • Membrane Cholesterol and Ethanol: Domains, Kinetics, and Protein Function

    Wood, W. Gibson (et al.)

    Pages 13-32

  • The Effects of Ethanol on Polyunsaturated Fatty Acid Composition

    Salem, Norman, Jr. (et al.)

    Pages 33-46

  • Revelant Effects of Dietary Polyunsaturated Fatty Acids on Synaptic Membrane Responses to Ethanol and Chronic Alcohol Intoxication

    Beaugé, Françoise J.

    Pages 47-53

  • Chronic Ethanol Treatment Increases the Incorporation of [14C]-Serine into Phosphatidylserine in Neuroblastoma X Glioma Cells

    Rodríguez, F. David (et al.)

    Pages 55-62

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-1-4615-2470-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $79.99
price for USA in USD
  • ISBN 978-1-4613-6052-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Alcohol, Cell Membranes, and Signal Transduction in Brain
Editors
  • Christer Alling
  • Ivan Diamond
  • Steven W. Leslie
  • Grace Y. Sun
  • W. Gibson Wood
Copyright
1993
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4615-2470-0
DOI
10.1007/978-1-4615-2470-0
Softcover ISBN
978-1-4613-6052-0
Edition Number
1
Number of Pages
XIII, 320
Topics