Alcohol, Cell Membranes, and Signal Transduction in Brain

1. Front Matter

   Pages i-xiii

   PDF

2. Lipid Structure, Domains and Proteins

   1. Molecular Mechanisms of Ethanol and Anesthetic Actions: Lipid- and Protein-Based Theories

      • Christopher D. Stubbs, Emanuel Rubin

      Pages 1-11

   2. Membrane Cholesterol and Ethanol: Domains, Kinetics, and Protein Function

      • W. Gibson Wood, A. Muralikrishna Rao, Friedhelm Schroeder, Urule Igbavboa

      Pages 13-32

   3. The Effects of Ethanol on Polyunsaturated Fatty Acid Composition

      • Norman Salem Jr., Glenn Ward

      Pages 33-46

   4. Revelant Effects of Dietary Polyunsaturated Fatty Acids on Synaptic Membrane Responses to Ethanol and Chronic Alcohol Intoxication

      • Françoise J. Beaugé

      Pages 47-53

   5. Chronic Ethanol Treatment Increases the Incorporation of [14C]-Serine into Phosphatidylserine in Neuroblastoma X Glioma Cells

      • F. David Rodríguez, Christer Alling, Lena Gustavsson

      Pages 55-62

   6. Ethanol-Induced Changes in Signal Transduction via Formation of Phosphatidylethanol

      • Lena Gustavsson, Christofer Lundqvist, Elisabeth Hansson, F. David Rodríguez, Per Simonsson, Christer Alling

      Pages 63-73

   7. Phosphatidylethanol Effects on Inositol 1,4,5-Trisphosphate Levels and Protein Kinase C Activity in NG108-15 Cells

      • Christofer Lundqvist, Christer Larsson, Christer Alling, Lena Gustavsson

      Pages 75-82

   8. Multiple Actions of Ethanol on Acetylcholine Receptors

      • Keith W. Miller

      Pages 83-96

3. Receptors and Ion Channels

   1. Sensitivity of NMDA Receptors to Acute and in Utero Ethanol Exposure

      • Steven W. Leslie, Melanie S. Weaver

      Pages 97-106

   2. Neurotransmitter-Gated Ion Channels as Molecular Sites of Alcohol Action

      • Forrest F. Weight, Robert W. Peoples, Jerry M. Wright, Chaoying Li, Luis G. Aguayo, David M. Lovinger et al.

      Pages 107-122

   3. Molecular Mechanisms of Alcohol Neurotoxicity

      • Fulton T. Crews, Hunter Newsom, Mark Gerber, Colin Sumners, L. Judson Chandler, Gerhard Freund

      Pages 123-138

   4. Molecular Properties of an NMDA Receptor Complex and Effects of Ethanol on the Expression of this Complex

      • Elias K. Michaelis, Mary L. Michaelis, Keshava N. Kumar

      Pages 139-149

   5. In Vivo Studies of Ethanol Interactions with N-Methyl-D-Aspartate Systems in Rat Brain

      • Lynn C. Roper, Rueben A. Gonzales

      Pages 151-156

   6. Actions of Alcohols and other Sedative/Hypnotic Compounds on Cation Channels Associated with Glutamate and 5-HT3 Receptors

      • David M. Lovinger, Robert W. Peoples

      Pages 157-167

   7. Mechanisms that Mediate Ethanol-Induced Increases in Dihydropyridine-Sensitive Calcium Channels

      • Robert O. Messing

      Pages 169-174

   8. Alcohol: Effects on GABAA Receptor Function and Gene Expression

      • Molina C. Mhatre, Maharaj K. Ticku

      Pages 175-183

   9. Control of Alcoholism by Treatment with SKV, A Herbal Drug Mixture from India

      • V. Nachiappan, K. R. Shanmugasundaram, S. I. Mufti

      Pages 185-193

4. Second Messenger Systems and Kinases

   1. Nucleoside Transport and Ethanol-Induced Heterologous Desensitization

      • Adrienne Gordon, Mohan K. Sapru, Sharon W. Krauss, Ivan Diamond

      Pages 195-203

   2. Effects of Acute and Chronic Ethanol Administration on the Poly-Phosphoinositide Signaling Activity in Brain

      • Grace Y. Sun, Jian-ping Zhang, Tai-An Lin

      Pages 205-218

Alcohol abuse and alcoholism are international problems whose costs economical­ ly, psychologically and medically have been well documented. Alcohol is a unique drug in that the effects of excessive use can have a deleterious effect on most if not all organs of the body. The brain is one of the organs most affected by excessive alcohol consumption. Effects on the brain can be seen in cognitive function, brain structure and neurochemistry. Over the past few years, there have been significant advances made in understanding how alcohol affects brain neurochemistry. This book examines four major areas, i. e. , membrane lipids, receptors and ion channels, second messengers, and gene expression, where significant advancements have been made. The book is divided into four sections based on the four major areas. In each section, data are examined that cover a range of approaches from in vitro to in vivo studies. The section on membrane lipids includes recent developments in how ethanol affects membrane cholesterol domains, polyunsaturated fatty acids, the cause and consequences of phosphatidylethanol formation, and the modulation of membrane protein function by lipid-protein interaction. The second section comprises chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol neurotoxicity and the molecular heterogeneity that may underlie differences in alcohol sensitivity as well as chapters on GABA-gated chloride flux, and calcium channels.

• Calcium
• Lipid
• calcium channels
• gene expression
• genes
• molecular mechanisms
• signal transduction
• transcription

• University of Lund, Lund, Sweden

  Christer Alling

• The Ernest Gallo Clinic and Research Center, University of California, San Francisco, USA

  Ivan Diamond

• The University of Texas at Austin, Austin, USA

  Steven W. Leslie

• University of Missouri, Columbia, USA

  Grace Y. Sun

• Veterans Affairs Medical Center, University of Minnesota School of Medicine, Minneapolis, USA

  W. Gibson Wood

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