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Advances in Experimental Medicine and Biology

Free Radicals in Diagnostic Medicine

A Systems Approach to Laboratory Technology, Clinical Correlations, and Antioxidant Therapy

Editors: Armstrong, Donald (Ed.)

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About this book

An International Syaposiua on Free Radicals in Diagnostic Medicine was co-sponsored by the state University of New York at Buffalo, Roswell Park Cancer Institute, and the Upstate NY Section of the American Association of Clinical Chemistry. The theme was "A Systems Approach To Laboratory Technology, Clinical Correlations And Antioxidant Therapy." The symposium was held on October 7-8, 1993 at the Hyatt Hotel and on October 9 at Roswell Park Cancer Institute, Buffalo, New York. This proceedings volume contains chapters from platform presentations, poster sessions and from invited special lectures in the areas of basic science, clinical applications and efficacy of treatment. A Special Lecture on the relevance of free radical analysis to clinical medicine was presented by Professor Kunio Yagi of Japan. The Yagi procedure to measure thiobarbituric acid (TBA) reaction reflects the amount of reactive substances, lipid peroxides and aldehydes, in the sample. For example, normal subjects will have less than 4 nmol/ml of serum lipid peroxides, while a person with diabetes generally has equal or greater than 5.0 and a diabetic person with vascular complications often exceeds 7.5 nmol/ml. Serum TBA is a clinically important measure that relates to aging, gender and estrogen as an antioxidant, in the prognosis for vascular disorders, and in pathological conditions relative to the amount of lipid peroxidation. The BASIC SCIENCES portion of the program examined: "Mechanisms of Action, Pathophysiology and Laboratory Tests" in six presentations.

Table of contents (50 chapters)

Table of contents (50 chapters)
  • Lipid Peroxides and Related Radicals in Clinical Medicine

    Pages 1-15

    Yagi, Kunio

  • Reactive Oxygen Species in Normal Physiology, Cell Injury and Phagocytosis

    Pages 17-27

    Moslen, Mary Treinen

  • Free Radical Mechanisms for Chromosomal Instability in Bloom’s Syndrome

    Pages 29-41

    Nicotera, Thomas M.

  • The Analysis of Free Radicals, Lipid Peroxides, Antioxidant Enzymes and Compounds Related to Oxidative Stress as Applied to the Clinical Chemistry Laboratory

    Pages 43-58

    Armstrong, Donald (et al.)

  • Free Radicals and the Pathogenesis of Neuronal Death: Cooperative Role of Excitatory Amino Acids

    Pages 59-71

    Pellegrini-Giampietro, Domenico E.

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-1-4615-1833-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $79.99
price for USA in USD
  • ISBN 978-1-4613-5742-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Free Radicals in Diagnostic Medicine
Book Subtitle
A Systems Approach to Laboratory Technology, Clinical Correlations, and Antioxidant Therapy
Editors
  • Donald Armstrong
Series Title
Advances in Experimental Medicine and Biology
Series Volume
366
Copyright
1994
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-1833-4
DOI
10.1007/978-1-4615-1833-4
Softcover ISBN
978-1-4613-5742-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XVI, 464
Topics