Overview
- Editors:
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David Kobiler
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Israel Institute for Biological Research, Ness-Ziona, Israel
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Shlomo Lustig
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Israel Institute for Biological Research, Ness-Ziona, Israel
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Shlomo Shapira
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Israel Institute for Biological Research, Ness-Ziona, Israel
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Table of contents (32 chapters)
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- Joseph D. Fenstermacher, Tavarekere Nagaraja, Kenneth R. Davies
Pages 1-7
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- Lester R. Drewes, David Z. Gerhart, Richard L. Leino, Bradley E. Enerson
Pages 9-17
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- Jean-François Ghersi-Egea, Nathalie Strazielle, Marie-Françoise Belin
Pages 19-25
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- N. Joan Abbott, Andreas Reichel, Mansoor Chishty, Kevin D. Read, Janet A. Taylor, David J. Begley
Pages 27-44
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- Thorsten Nitz, Tanja Eisenblätter, Matthias Haselbach, Hans-Joachim Galla
Pages 45-62
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- Shailesh Y. Desai, Mark A. McAllister, Kristine Goodrich, Marc M. Mayberg, Damir Janigro
Pages 63-70
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- M. Spatz, Y. Chen, J. Bembry, F. A. Lenz, E. Shohami, Raphael Mechoulam et al.
Pages 71-82
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- A. G. De Boer, P. J. Gaillard, I. C. J. Van Der Sandt, E. C. M. De Lange, D. D. Breimer
Pages 83-97
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- Michael Polyak, Oran Ayalon, Marina Vinnikova, Itzchak Angel, Alex Kozak
Pages 99-112
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- Alan J. Wilson, Miriam M. Boxer
Pages 113-122
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- Yoram Cohen, Yaniv Assaf, Revital Nossin-Manor, Inbal E. Biton
Pages 123-145
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- M. B. H. Youdim, K. L. Leenders, D. Ben-Shachar
Pages 147-156
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- Joerg R. Weber, Elaine I. Tuomanen
Pages 169-176
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- David Kobiler, David Ben-Nathan, Charles M. Rice, Paula Schneider, Menachem Halevy, Shlomo Lustig
Pages 191-204
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- Carol Shoshkes Reiss, Nannan Chen
Pages 205-216
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- Ela Shai, Amos Panet, Haya Falk, Aaron Palmon
Pages 217-225
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- Haim Ovadia, Oded Abramsky, Anna Itzik, Tali Siegal
Pages 227-231
About this book
The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, although the anatomic substrate of the BBB is the interendothelial tight junctions that form a continuous sealing. The BBB serves as an exquisitely controlled, functional gate to the eNS. It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the eNS, including neoplasia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The development of in vitro models of the BBB had instrumental role in the understanding of the involvement of the BBB in the pathogenesis of several eNS diseases. The intimate, functional association between the function of the brain and the activity of the BBB makes the later a target for pharmacological modulation that will expand the therapeutic possibilities for a range of neurological diseases.