Blood-Brain Barrier

Drug Delivery and Brain Pathology

Editors: Kobiler, David, Lustig, Shlomo, Shapira, Shlomo (Eds.)

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About this book

The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, although the anatomic substrate of the BBB is the interendothelial tight junctions that form a continuous sealing. The BBB serves as an exquisitely controlled, functional gate to the eNS. It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the eNS, including neoplasia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The development of in vitro models of the BBB had instrumental role in the understanding of the involvement of the BBB in the pathogenesis of several eNS diseases. The intimate, functional association between the function of the brain and the activity of the BBB makes the later a target for pharmacological modulation that will expand the therapeutic possibilities for a range of neurological diseases.

Table of contents (32 chapters)

Table of contents (32 chapters)
  • Overview of the Structure and Function of the Blood-Brain Barrier in vivo

    Fenstermacher, Joseph D. (et al.)

    Pages 1-7

  • Expression and Modulation of Blood-brain Monocarboxylate Transporters

    Drewes, Lester R. (et al.)

    Pages 9-17

  • Neuroprotective and Detoxifying Mechanisms at the Blood-Brain Interfaces

    Ghersi-Egea, Jean-François (et al.)

    Pages 19-25

  • Measurement and Prediction of Blood-Brain Barrier Permeability

    Abbott, N. Joan (et al.)

    Pages 27-44

  • Recent Advances in the Development of Cell Culture Models for the Blood-Brain- and Blood-CSF-Barrier

    Nitz, Thorsten (et al.)

    Pages 45-62

Buy this book

eBook n/a
  • ISBN 978-1-4615-0579-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
Softcover n/a
  • ISBN 978-1-4613-5141-2
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Blood-Brain Barrier
Book Subtitle
Drug Delivery and Brain Pathology
Editors
  • David Kobiler
  • Shlomo Lustig
  • Shlomo Shapira
Copyright
2001
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-0579-2
DOI
10.1007/978-1-4615-0579-2
Softcover ISBN
978-1-4613-5141-2
Edition Number
1
Number of Pages
XII, 434
Topics