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Immunochemistry of Proteins

Volume 1

Editors: Atassi, M.Zouhair (Ed.)

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About this book

The structural features responsible for the immunogenicity of certain parts of native protein molecules have been of interest to immunochemists and protein chemists for over three decades. Following the early work of Land­ steiner in 1942, which showed that peptide fragments from silk fibroin exhibited an inhibitory activity toward the reaction of the protein with its antibodies, fragments from many other protein systems have been isolated and studied. However, no concerted effort was (or could be) devoted to the elucidation of the complete antigenic structure of a protein. In order for these endeavors to be successful and meaningful, knowledge of both the amino acid sequence and the detailed three-dimensional structure of the protein is necessary. Such information was not available for a protein until early in the 1960s. This and the fact that protein chemistry was not in fact sufficiently developed early in the 1960s to enable the successful completion of the entire antigenic structure of a protein were major contributing factors for the slow progress in this field. Determination of the antigenic structures of proteins therefore posed a chemical challenge of enormous proportions. For these reasons, many investigators diverted their attention to study of the immunochemistry of homo- or mixed amino acid polymers in the hope that the information derived from these systems might prove useful in the understanding of the immunochemistry of proteins.

Table of contents (7 chapters)

Table of contents (7 chapters)
  • Chemical Modification and Cleavage of Proteins and Chemical Strategy in Immunochemical Studies of Proteins

    Pages 1-161

    Atassi, M. Z.

  • Influence of Conformation on Immunochemical Properties of Proteins

    Pages 163-229

    Habeeb, A. F. S. A.

  • Investigation of Immunochemical Reactions by Fluorescence Polarization

    Pages 231-261

    Dandliker, Walter B.

  • In Vitro Immune Responses of Lymphoid Cell Populations to Proteins and Peptides

    Pages 263-314

    Stavitsky, Abram B.

  • Immunochemistry of Encephalitogenic Protein

    Pages 315-370

    Bergstrand, Håkan

Buy this book

eBook $84.99
price for USA in USD
  • ISBN 978-1-4613-4190-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4613-4192-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Immunochemistry of Proteins
Book Subtitle
Volume 1
Editors
  • M.Zouhair Atassi
Copyright
1977
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4613-4190-1
DOI
10.1007/978-1-4613-4190-1
Softcover ISBN
978-1-4613-4192-5
Edition Number
1
Number of Pages
XVI, 486
Number of Illustrations
1 b/w illustrations
Topics