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Manual of Pharmacologic Calculations

With Computer Programs

  • Book
  • © 1987

Overview

Authors:
  1. Ronald J. Tallarida

    1. Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA

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    You can also search for this author in PubMed   Google Scholar

  2. Rodney B. Murray

    1. Department of Pharmacology, Biosearch Inc., Philadelphia, USA

    View author publications

    You can also search for this author in PubMed   Google Scholar

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Table of contents (49 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Introduction

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 1-4

  3. Dosage and Cosncentration: Drug Stock Solutions

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 5-7

  4. Mean, Standard Deviation, and Confidence Limits

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 7-10

  5. Linear Regression I

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 10-13

  6. Linear Regression II: Lines through Origin

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 13-15

  7. Analysis of the Regression Line

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 16-18

  8. Parallel Lines I: Test for Parallelism

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 19-22

  9. Parallel Lines II: Construction of Parallel Lines

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 22-26

  10. Graded dose—response

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 26-31

  11. Quantal Dose—Response: Probits

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 31-34

  12. Relative Potency I

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 35-38

  13. Relative Potency II: Statistical Analysis (Graded Data)

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 38-44

  14. Dissociation Constant I: Agonists

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 44-47

  15. Dissociation Constant II: Partial Agonists

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 47-50

  16. Dissociation Constant III: Perturbation Methods (Rate Constants in the Drug-Receptor Reaction)

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 50-53

  17. pA2 Analysis I: Schild Plot

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 53-56

  18. pA2 Analysis II: Time-Dependent Method

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 56-58

  19. pA2 Analysis III: Constrained Plot

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 59-61

  20. Enzyme Kinetics I: Michaelis—Menten Equation

    • Ronald J. Tallarida, Rodney B. Murray
    Pages 61-63
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Keywords

About this book

This book contains a collection of quantitative procedures in common use in pharmacology and related disciplines. It is intended for students and researchers in all fields who work with drugs. Many physicians, especially those concerned with clinical pharmacology, will also find much that is useful. The procedures included may be considered "core" since they are generally applicable to all classes of drugs. Some of the procedures deal with statistics and, hence, have even wider application. In this new edition we have increased the number of procedures from 33 (in the first edition) to 48. Other procedures have been revised and expanded. Yet the basic philosophy of this new edition remains unchanged from the first. That is, the pharmacologic basis of each procedure is presented, along with the necessary formulas and one or more worked examples. An associated computer program is included for each procedure and its use is illustrated with the same worked example used in the text. The discussions of theory and the sample computations are brief and self-contained, so that all computations can be made with the aid of a pocket calculator and the statistical tables contained in Appendix A. Yet it is realized that the proliferation of lower-priced microcom­ puters is likely to mean that more and more readers will utilize a computer for most calculations. Accordingly, we have modified the format of the book to facilitate computer usage.

Authors and Affiliations

  • Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA

    Ronald J. Tallarida

  • Department of Pharmacology, Biosearch Inc., Philadelphia, USA

    Rodney B. Murray

Bibliographic Information

  • Book Title: Manual of Pharmacologic Calculations

  • Book Subtitle: With Computer Programs

  • Authors: Ronald J. Tallarida, Rodney B. Murray

  • DOI: https://doi.org/10.1007/978-1-4612-4974-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York Inc. 1987

  • Softcover ISBN: 978-1-4612-9380-4Published: 01 October 2011

  • eBook ISBN: 978-1-4612-4974-0Published: 06 December 2012

  • Edition Number: 2

  • Number of Pages: X, 297

  • Topics: Pharmacology/Toxicology, Health Informatics, Computer Appl. in Life Sciences, Pharmacy

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