Get 40% off select Statistics books or choose from thousands of Archive eBooks at 9.99 each!

Rochester Series on Environmental Toxicity

The Cytoskeleton

A Target for Toxic Agents

Authors: Clarkson, Thomas W., Sager, Polly R., Syversen, Tore L.M.

Free Preview

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4613-2161-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.99
price for USA in USD
  • ISBN 978-1-4612-9274-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book is based on reviews and research presentations given at the 16th Rochester International Conference on Environmental Toxicity, entitled liThe Cytoskeleton: A Target for Toxic Agents," held on June 4, 5 and 6 in 1984. The conference provided an in-depth discussion of the effects a~d mechanism of action of some toxic agents on the cytoskeleton. Mamma"lian and other eukaryotic cells contain protein networks within the cytoplasm comprised of microfilaments, intermediate Hlaments and microtubules. These components of the cytoskeleton playa key role in cell shape, motility, intracellular organization and transport, and cell division. Furthermore, the cytoskeleton, via associations with the cell membrane, appears to function in intracellular communication and cellular responses to membrane events. Because of the complex functional roles of the cytoskeleton which vary with cell type, degree of differentiation, and cell cycle, its disruption may result in a variety of cellular changes. This expanding field in cell biology has already attracted the interest of toxicologists and environmental health scientists as a potentially fruitful area of research. Indeed, there is mounting evidence that certain toxic and chemotherapeutic compounds, as well as physical agents such as radiation and hydrostatic pressure, disrupt the normal structure and function of the cytoskeleton. This may be an important step in the overall expression of their action. It was, therefore, an opportune time to hold a conference to encourage the development of this area of toxicology and to suggest directions for future research.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • Structure and Function of the Cytoskeleton

    Pages 3-21

    Sager, Polly R. (et al.)

  • The Cytoskeleton as a Target For Toxic Agents

    Pages 25-34

    Syversen, Tore L. M. (et al.)

  • Microtubules as Targets for Drug and Toxic Chemical Action: The Mechanisms of Action of Colchicine and Vinblastine

    Pages 37-52

    Wilson, Leslie

  • Taxol: A Probe for Studying the Structure and Function of Microtubules

    Pages 53-65

    Horwitz, Susan B. (et al.)

  • Reorganization of Axonal Cytoskeleton Following β, β′-Iminodipropionitrile (IDPN) Intoxication

    Pages 67-82

    Papasozomenos, Sozos Ch.

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4613-2161-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.99
price for USA in USD
  • ISBN 978-1-4612-9274-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
The Cytoskeleton
Book Subtitle
A Target for Toxic Agents
Authors
Series Title
Rochester Series on Environmental Toxicity
Copyright
1986
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4613-2161-3
DOI
10.1007/978-1-4613-2161-3
Softcover ISBN
978-1-4612-9274-6
Edition Number
1
Number of Pages
XIV, 261
Topics