Gene Regulation by Steroid Hormones IV

Editors: Roy, Arun K., Clark, James H. (Eds.)

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About this book

The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds. In this volume, which sum­ marizes our fourth meeting, these advances are very evident. What seemed like science fiction ten years ago has become commonplace science. Who would have imagined that we could synthesize a nucleotide sequence that binds a specific steroid receptor and acts as a controlling element for gene expression? No one; but as is evident from the results reported in several chapters, this technique is yielding a wealth of information. Using these and other techniques it has become apparent that gene transcription is controlled by interactions between transacting factors and DNA recognition sequences (response elements). These transacting factors appear to be members of a large gene family that includes steroid hormone receptors, transcription factors, protooncogenes and homeobox proteins. Thus a great deal has been learned, but as usual, questions remain. Many of these questions are posed by the findings and observations found in several chapters in this volume. Non­ hormone binding forms of steroid receptors and their relevance to receptor down regulation, recycling and biological response remain a mystery. The quantitative relationship between receptor binding and biological response still presents agonizing problems. These and many other intriguing questions are discussed in this volume and set the stage for what should be a most rewarding time in endocrinology. Winter 1989 ARUN K.

Table of contents (14 chapters)

Table of contents (14 chapters)
  • Towards a Molecular Understanding of Steroid Binding to Glucocorticoid Receptors

    Pages 1-22

    Simons, S. Stoney, Jr.

  • Regulation of Glucocorticoid Receptor Protein and Gene Expression by Glucocorticoids

    Pages 23-40

    Wang, Yan Min (et al.)

  • Modulation of Glucocorticoid-Induced Responses by Cyclic AMP in Lymphoid Cell Lines

    Pages 41-61

    Gruol, Donald J. (et al.)

  • Differential Regulation of Tyrosine Amino-Transferase by Glucocorticoids: Transcriptional and Post-Transcriptional Control

    Pages 63-77

    Thompson, E. Brad (et al.)

  • Steroid Response Elements. Definition of a Minimal Promoter and Interaction with Other Activating Sequences

    Pages 78-89

    Schmid, W. (et al.)

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-1-4612-3666-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $199.99
price for USA in USD
  • ISBN 978-1-4612-8197-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Gene Regulation by Steroid Hormones IV
Editors
  • Arun K. Roy
  • James H. Clark
Copyright
1989
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York, Inc.
eBook ISBN
978-1-4612-3666-5
DOI
10.1007/978-1-4612-3666-5
Softcover ISBN
978-1-4612-8197-9
Edition Number
1
Number of Pages
XI, 239
Topics