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Fibronectins

  • Book
  • © 1990

Overview

Authors:
  1. Richard O. Hynes

    1. Department of Biology Massachusetts Institute of Technology, Howard Hughes Medical Institute and Center for Cancer Research, Cambridge, USA

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Part of the book series: Springer Series in Molecular and Cell Biology (SSMOL)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xv
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  2. Introduction and Historical Overview

    • Richard O. Hynes
    Pages 1-6

  3. Methods for Identification of Fibronectins

    • Richard O. Hynes
    Pages 7-23

  4. Distribution of Fibronectins in Vivo

    • Richard O. Hynes
    Pages 24-48

  5. Expression of Fibronectins by Cells in Culture

    • Richard O. Hynes
    Pages 49-83

  6. Interactions of Fibronectins

    • Richard O. Hynes
    Pages 84-112

  7. Structure of Fibronectins

    • Richard O. Hynes
    Pages 113-175

  8. Biosynthesis and Fibrillogenesis

    • Richard O. Hynes
    Pages 176-199

  9. Cellular Adhesion and Cell Surface Receptors

    • Richard O. Hynes
    Pages 200-230

  10. Fibronectin and the Cytoskeleton

    • Richard O. Hynes
    Pages 231-248

  11. Fibronectin and the Cytoskeleton

    • Richard O. Hynes
    Pages 249-280

  12. Development and Differentiation

    • Richard O. Hynes
    Pages 281-300

  13. Oncogenic Transformation

    • Richard O. Hynes
    Pages 301-334

  14. Hemostasis and Thrombosis

    • Richard O. Hynes
    Pages 335-348

  15. Wound Healing, Inflammation, and Fibrosis

    • Richard O. Hynes
    Pages 349-364

  16. Phagocytosis and Interactions with Pathogenic Microorganisms

    • Richard O. Hynes
    Pages 365-379

  17. Implications for Future Research

    • Richard O. Hynes
    Pages 380-392

  18. Back Matter

    Pages 393-546
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Keywords

About this book

Fibronectins comprise a class of high molecular weight glycoproteins present both in extracellular matrices and in soluble form in body fluids. Although they have been studied for about forty years, their real significance emerged only during the past decade. Intensive research has focused on their role in platelet function, cell migration, the cytoskeleton, reticuloendothelial function, and on alterations in fibronectin distribution during development and disease. Fibronectins have emerged as glycoproteins with a very interesting set of properties generally involving adhesion of cells to cells or to extracellular material. In more recent years, the complete sequences of several fibronectin molecules and their genes were determined, the relation between structure and function was understood and much has been learned about cell surface receptors for fibronectins and other adhesive ligands. Having been at the forefront of all these exciting developments, the author has synthesized the entire field and with all the latest information at hand for the first time given it a clear perspective.

Authors and Affiliations

  • Department of Biology Massachusetts Institute of Technology, Howard Hughes Medical Institute and Center for Cancer Research, Cambridge, USA

    Richard O. Hynes

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