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Aplastic Anemia and Other Bone Marrow Failure Syndromes

Editors: Shahidi, Nasrollah T. (Ed.)

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About this book

During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup­ pressive agents for bone marrow transplantation; failure to achieve en­ graftment in some identical twins without prior immunosuppressive ther­ apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia. Such a concept was further strengthened by laboratory findings, implicat­ ing the role of activated cytotoxic T lymphocytes and abnormal produc­ tion of inhibitory lymphokines. The immunologic mechanisms may also apply to the idiosyncratic bone marrow aplasias associated with drugs, toxic chemicals, and viruses. These agents may alter normal cellular recog­ nition sites by interacting with cellular components and result in loss of self tolerance. Immunologic mechanisms have long been advocated in many other organ failures, and the hemopoietic organ is no exception. It is of interest that parallel clinical and laboratory investigations in juvenile diabetes mellitus type I and in rodent models of this disease have yielded results compatible with the same pathogenic mechanisms. The infiltration of pancreatic islets by activated T lymphocytes, functional and morphological alterations of islet cells upon incubation with lymphokines such as gamma interferon and tumor necrosis factor, and clinical response to cyclosporine are a few examples.

Table of contents (18 chapters)

Table of contents (18 chapters)

Buy this book

eBook $99.00
price for USA in USD
  • ISBN 978-1-4612-3254-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $129.00
price for USA in USD
  • ISBN 978-1-4612-7935-8
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Aplastic Anemia and Other Bone Marrow Failure Syndromes
Editors
  • Nasrollah T. Shahidi
Copyright
1990
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag Inc.
eBook ISBN
978-1-4612-3254-4
DOI
10.1007/978-1-4612-3254-4
Softcover ISBN
978-1-4612-7935-8
Edition Number
1
Number of Pages
XVII, 236
Topics

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