Selenium in Biology and Human Health

1. Front Matter

   Pages i-xiv

   PDF

2. Introduction

   • Raymond F. Burk

   Pages 1-7

3. Incorporation of Selenium into Bacterial Selenoproteins

   • August Böck

   Pages 9-24

4. Selenocysteine tRNA[Ser]Sec Isoacceptors as Central Components in Selenoprotein Biosynthesis in Eukaryotes

   • Dolph L. Hatfield, In Soon Choi, Takeshi Ohama, Jae-Eon Jung, Alan M. Diamond

   Pages 25-44

5. Intracellular Glutathione Peroxidases — Structure, Regulation, and Function

   • Roger A. Sunde

   Pages 45-77

6. Extracellular Glutathione Peroxidase:A Distinct Selenoprotein

   • Harvey J. Cohen, Nelly Avissar

   Pages 79-91

7. Roles of Selenium in Type I Iodothyronine 5’-Deiodinase and in Thyroid Hormone and Iodine Metabolism

   • John R. Arthur, Geoffrey J. Beckett

   Pages 93-115

8. Selenoprotein P—An Extracellular Protein Containing Multiple Selenocysteines

   • Kristina E. Hill, Raymond F. Burk

   Pages 117-131

9. The Mitochondrial Capsule Selenoprotein—A Structural Protein in the Mitochondrial Capsule of Mammalian Sperm

   • Kenneth C. Kleene

   Pages 133-149

10. Selenium Status and Glutathione Metabolism

    • Kristina E. Hill

    Pages 151-167

11. Novel Strategies in Selenium Cancer Chemoprevention Research

    • Clement Ip, Howard E. Ganther

    Pages 169-180

12. Keshan Disease and Selenium Status of Populations in China

    • Yiming Xia, Jianhua Piao, Kristina E. Hill, Raymond F. Burk

    Pages 181-196

13. Nationwide Selenium Supplementation in Finland— Effects on Diet, Blood and Tissue Levels, and Health

    • Pertti Varo, Georg Alfthan, Jussi K. Huttunen, Antti Aro

    Pages 197-218

14. Back Matter

    Pages 219-221

    PDF

Selenium plays a fascinating and still poorly understood role in the function of living cells and therefore in human health. Starting with investigations over 60 years ago into its role as a toxic agent in livestock disease, selenium studies have progressed rapidly with the application of tools from immunology and molecular biology. Selenium is now known to be important in human and animal nutrition, has been discovered as a structural component of so-called selenoproteins, and may play a number of physiological roles, ranging from cancer protection to hormone metabolism. Selenium in Biology and Human Health presents research syntheses on a range of topics involving selenium, written by specialists from around the world. It will be of interest to cell biologists and physiologists, nutritional scientists, and animal health researchers.

• bacteria
• biology
• cancer
• cell
• immunology
• metabolism
• mitochondria
• molecular biology
• nutrition
• prevention
• protein
• proteins
• regulation
• synthesis
• tissue
• ecotoxicology

• Division of Gastroenterology Department of Medicine School of Medicine, Vanderbilt University, Nashville, USA

  Raymond F. Burk

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