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Topics in Environmental Physiology and Medicine

Short-Term Tests for Chemical Carcinogens

Editors: Stich, H.F., San, R.H.C. (Eds.)

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About this book

The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be­ tween the carcinogenicity and mutagenicity of chemicals and physical agents and by the assumption that DNA alteration, mutations, and chromosome aberrations are somehow involved in neoplastic transformation. Moreover, it has been tacitly assumed that the mutagenic capacity alone of compounds would induce regulatory agencies to pass rules for their removal from the environment and would lead the public to avoid them. The actual response, however, is quite different. Governmental departments shy away from making any decisions on the basis of in vitro test systems. The public at large is becoming irritated by daily an­ nouncements that many of their cherished habits could adversely affect their health. Industry appears to feel threatened and may reduce its search for new beneficial chemicals. The reluctance to accept wholeheartedly the mutagenicity tests for the detection of carcinogens is partly due to uncertainty about the in­ volvement of mutations in neoplastic transformation, partly due to the present difficulty of extrapolating results from various endpoints obtained on numerous organisms to man, and partly due to a multitude of complex events that lead in vivo to the evolvement of benign or malignant tumors.

Table of contents (44 chapters)

  • A Biochemical Phage Induction Assay for Carcinogens

    Elespuru, Rosalie K.

    Pages 1-11

  • Detection of DNA-Modifying Agents by Analyzing the Lesions Introduced into Purified PM2 DNA

    Kuhnlein, Urs (et al.)

    Pages 12-19

  • Reactivation of Viruses

    Rainbow, Andrew J.

    Pages 20-35

  • Metabolic Activation of Nitroheterocyclic Compounds in Bacteria and Mammalian Cells

    McCalla, D. R.

    Pages 36-47

  • Utilization of the Alkaline Elution Assay as a Short-Term Test for Chemical Carcinogens

    Swenberg, James A.

    Pages 48-58

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4612-5847-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4612-5849-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Short-Term Tests for Chemical Carcinogens
Editors
  • H.F. Stich
  • R.H.C. San
Series Title
Topics in Environmental Physiology and Medicine
Copyright
1981
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York Inc.
eBook ISBN
978-1-4612-5847-6
DOI
10.1007/978-1-4612-5847-6
Softcover ISBN
978-1-4612-5849-0
Series ISSN
0172-6048
Edition Number
1
Number of Pages
518
Topics