Hedgehog signaling activation in human cancer and its clinical implications

Editors: Jingwu, Xie (Ed.)

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  • Presents up-to-date information in this exciting research area
  • Summarizes major advances made on hedgehog signaling mechanisms, activation of the pathway in various human cancer types
  • Highlights current challenges in our efforts to translate the basic biology into clinic
  • Provides insightful views suitable for graduate, undergraduate, and medical students, basic and clinical scientists, cancer patients as well as the general public
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eBook $169.00
price for USA in USD
  • ISBN 978-1-4419-8435-7
  • Digitally watermarked, DRM-free
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  • Bulk discounts from 10 eBooks
Hardcover $249.99
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Softcover $219.99
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About this book

Despite significant progress in our understanding of cancer biology, cancer continues to be the second cause of human mortality. The remarkable responses of cancer patients to inhibitors to the hedgehog signaling pathway implies a promising novel approach to treat cancer. As a result, understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway, initially discovered by two Nobel laureates Drs. E. Wieschaus and C. Nusslein-Volhard in Drosophila, is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. Even more exciting is the discovery and synthesis of specific signaling antagonists for the hedgehog pathway, which have significant clinical implications in novel cancer therapeutics. To provide the most up-to-date information on recent development in this exciting research area, we have invited experts in hedgehog signaling field to summarize major advances made in the last few years on hedgehog signaling mechanisms, activation of the pathway in various human cancer types, potential antagonists for hedgehog signaling inhibition and their clinical implications for human cancer treatment. Authors of the book have also highlighted current challenges in our efforts to translate the basic biology into clinic. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.

Table of contents (12 chapters)

Table of contents (12 chapters)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-1-4419-8435-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts from 10 eBooks
Hardcover $249.99
price for USA in USD
Softcover $219.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Hedgehog signaling activation in human cancer and its clinical implications
Editors
  • Xie Jingwu
Copyright
2011
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-8435-7
DOI
10.1007/978-1-4419-8435-7
Hardcover ISBN
978-1-4419-8434-0
Softcover ISBN
978-1-4899-9541-4
Edition Number
1
Number of Pages
IX, 217
Topics