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Characterization of Protein Therapeutics using Mass Spectrometry

  • Book
  • © 2013

Overview

Editors:
  1. Guodong Chen

    1. , Bioanalytical and Discovery Analytical S, Bristol-Myers Squibb, Princeton, USA

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  • First book to focus on characterization by mass spectrometry of protein drugs
  • Well-known Volume Editor with strong ties to pharmaceutical industry and analytical chemistry
  • Internationally recognized contributors who are top experts in the field

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
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  2. Introduction to Protein Mass Spectrometry

    • Ismael Cotte-Rodriguez, Zhixin Miao, Yun Zhang, Hao Chen
    Pages 1-58

  3. Quantitative Analysis of Therapeutic and Endogenous Peptides using LC/MS/MS Methods

    • Erin E. Chambers
    Pages 59-94

  4. The Development and Implementation of LC/MS-Based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug Discovery

    • Timothy V. Olah, Asoka Ranasinghe, Hongwei Zhang, Richard L. Wong, John Mehl, Dieter M. Drexler et al.
    Pages 95-115

  5. Post-Translationally Modified Proteins: Glycosylation and Disulfide Bond Formation

    • Anthony Tsarbopoulos, Fotini N. Bazoti
    Pages 117-162

  6. Mass Spectrometric Characterization in Protein Therapeutics Discovery

    • Jingjie Mo, Adrienne A. Tymiak, Guodong Chen
    Pages 163-205

  7. Molecular Variants Characterization in Protein Therapeutics Development

    • Richard Ludwig, Jacob Bongers, Li Tao, Yunping Huang, Jinmei Fu, Wei Wu et al.
    Pages 207-277

  8. Mass Spectrometry of Antibody–Drug Conjugates in Plasma and Tissue in Drug Development

    • Surinder Kaur, Keyang Xu, Ola Saad, Luna Liu, Tim Slattery, Randall Dere
    Pages 279-304

  9. Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization

    • Hui Wei, Adrienne A. Tymiak, Guodong Chen
    Pages 305-341

  10. Fast Photochemical Oxidation of Proteins for Structural Characterization

    • Lisa M. Jones
    Pages 343-370

  11. Applications of Ion Mobility Mass Spectrometry for Characterization of Protein Therapeutics

    • Weibin Chen, Asish Chakraborty
    Pages 371-401

  12. Back Matter

    Pages 403-404
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Keywords

About this book

This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.

Editors and Affiliations

  • , Bioanalytical and Discovery Analytical S, Bristol-Myers Squibb, Princeton, USA

    Guodong Chen

About the editor

GUODONG CHEN, PHD, has extensive pharmaceutical research experience in major pharmaceutical companies, including Eli Lilly and Company, Schering-Plough and Bristol-Myers Squibb. Currently, he heads the analytical/mass spectrometry group at Bristol-Myers Squibb’s Princeton site in support of drug discovery programs and development projects in small molecule pharmaceuticals and biologics. He has over 65 research publications in peer-reviewed journals and book chapters, and three edited/co-edited books in pharmaceutical analysis. His other contributions to the scientific community include over 80 presentations at scientific conferences and academic institutes; service as a short course instructor, as session chair at various scientific forums, and as a reviewer for journals. He received his Ph.D. in Analytical Chemistry from Purdue University under the direction of Professor R. Graham Cooks. 

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