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Immunologic Signatures of Rejection

Editors: Marincola, Francesco M., Wang, Ena (Eds.)

  • Discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most pathologies and it is relatively simple
  • Several disease processes are discussed including chronic inflammatory process without resolution of the pathologic process
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4419-7219-4
  • Digitally watermarked, DRM-free
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  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4419-7218-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4899-8243-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book collects salient observational data, derived predominantly from human studies, regarding the mechanism(s) of rejection in various pathologic conditions; the premise is that immune rejection, better defined as “immune-mediated, tissue-specific destruction” (TSD), comprises a broad range of phenomena ranging from tumor regression, to clearance of pathogen through destruction of infected cells, autoimmunity, allograft rejection by the host and host versus graft reactions. Like different hands can turn on or off a switch, distinct mechanisms can trigger TSD; however, a convergent pathway is ultimately observed when TSD occurs consisting of a dramatic switch from chronic to acute inflammation leading to the activation of a restricted number of genes that we comprise in the immunologic constant of rejection (ICR) model. Although the ICR model does not address “why” rejection occurs but rather “how”, and it may not contribute an explanation for the determinism of rejection, it provides, if correct, a simplified road map about the convergent pathways leading to TSD. This offers the opportunity to identify a common target for immune manipulation with therapeutic purposes since ICR-related pathways are restricted in expression to the tissues in which TSD occurs while are shut off in the rest of a normal organism. The book includes chapters from outstanding basic and/or observational scientists that have contributed to this area either by defining mechanisms relevant to the understanding of the inflammatory switch or by describing how this occurs in human tissues under different pathological conditions. We would like to entice our reader(s) to test with us, through, the readings, whether our hypothesis is correct; we predict that common themes will emerge particularly if attention will be paid to the general phenomenon of TSD rather than the peculiarities of individual pathologies. With the hope of having contributed with this book something novel and important and we wish our reader a pleasant journey in the wondrous land of immune-mediated, tissue-specific destruction.

Table of contents (19 chapters)

  • From the “Delayed Allergy Reaction” to the “Immunologic Constant of Rejection”

    Wang, Ena (et al.)

    Pages 3-8

  • The Yin Yang of Cancer Related Inflammation

    Mantovani, Alberto (et al.)

    Pages 11-16

  • The Immune Rejection: Lessons from Experimental Models

    Shanker, Anil

    Pages 17-25

  • Turning on and off the Immunological Switch: Immune Response Polarization and Its Control by IL-10 and STAT3

    Stewart, C. Andrew (et al.)

    Pages 27-55

  • The Angiogenic Switch: Role of Immune Cells

    Noonan, Douglas M. (et al.)

    Pages 57-75

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4419-7219-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-1-4419-7218-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4899-8243-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Immunologic Signatures of Rejection
Editors
  • Francesco M. Marincola
  • Ena Wang
Copyright
2011
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-7219-4
DOI
10.1007/978-1-4419-7219-4
Hardcover ISBN
978-1-4419-7218-7
Softcover ISBN
978-1-4899-8243-8
Edition Number
1
Number of Pages
VII, 353
Topics