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Systems Biology

BetaSys

Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells

Editors: Booß-Bavnbek, B., Kloesgen, B., Larsen, J., Pociot, F., Renström, E. (Eds.)

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  • Uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications
  • In using a focused approach here by picking one outlook, the topic of Systems Biology is made more accessible
  • Systems Biology is a fast moving field, but the work presented here emphasizes the principal aspects of the field, making this a tool for on-going research
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eBook $219.00
price for USA in USD
  • ISBN 978-1-4419-6956-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
Softcover $279.99
price for USA in USD
About this book

The insulin secreting β-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the β-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.

Reviews

From the reviews:

“This second volume is Springer’s Systems Biology series focuses on the organisation of pancreatic insulin-producing beta cells, with a particular focus on the technological approaches deemed necessary to further our understanding of beta cell physiology and the pathogenesis of diabetes. … I warmly recommend should be on the shelves of all research laboratories involved in modern beta cell research.” (P. Meda, Diabetologia, Vol. 54, 2011)

Table of contents (23 chapters)

Table of contents (23 chapters)
  • Systems Biology of the β-Cell – Revisited

    Pages 3-23

    Pociot, Flemming

  • Established Facts and Open Questions of Regulated Exocytosis in β-Cells – A Background for a Focused Systems Analysis Approach

    Pages 25-52

    Renström, Erik

  • Mitochondria and Metabolic Signals in β-Cells

    Pages 53-71

    Maechler, Pierre

  • β-Cell Ontogenesis and the Insulin Production Apparatus

    Pages 73-81

    Heller, R. Scott (et al.)

  • The Role of the Cytoskeleton in Transport and Release of Insulin-Containing Granules by Pancreatic β-Cells

    Pages 83-95

    Goody, Roger S. (et al.)

Buy this book

eBook $219.00
price for USA in USD
  • ISBN 978-1-4419-6956-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
Softcover $279.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
BetaSys
Book Subtitle
Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells
Editors
  • Bernhelm Booß-Bavnbek
  • Beate Kloesgen
  • Jesper Larsen
  • Flemming Pociot
  • Erik Renström
Series Title
Systems Biology
Copyright
2011
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-6956-9
DOI
10.1007/978-1-4419-6956-9
Hardcover ISBN
978-1-4419-6955-2
Softcover ISBN
978-1-4614-2815-2
Series ISSN
2191-222X
Edition Number
1
Number of Pages
XX, 556
Topics