Advances in Experimental Medicine and Biology

Neuropeptide Systems as Targets for Parasite and Pest Control

Editors: Geary, Timothy G., Maule, Aaron (Eds.)

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  • Provides an overview of the organism-level biology of neuropeptidergic function in insects and helminths
  • Discusses the discovery of insecticides and anthelmintics
  • Reviews drugs that affect similar systems in nematodes
  • Summary of drug discovery efforts that target mammalian neuropeptide receptors for therapy of non-infectious diseases in humans
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About this book

The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.

About the authors

TIMOTHY G. GEARY is a Tier I Canada Research Chair and is Professor and Director of the Institute of Parasitology at McGill University in Montréal, Québec, Canada. Geary received a BSc degree from the University of Notre Dame in South Bend, IN (USA) and a PhD in Pharmacology from the University of Michigan in Ann Arbor, MI (USA, 1980). He worked on malaria chemotherapy at Michigan State University in East Lansing, MI (USA) until 1985, when he joined The Upjohn Company in Kalamazoo, MI (USA) as a staff scientist working on discovery of antiparasitic drugs. Geary joined the Faculty at McGill in 2005; research interests include proteomics and genomics analyses of the host-parasite interface, discovery of anthelmintics and the pharmacology of antiparasitic drugs. AARON G. MAULE is a Director of Research for Molecular Biosciences and Professor of Molecular Parasitology at Queen’s University Belfast, Northern Ireland. Maule was awarded a BSc(Hons) in Biology (1986) and a PhD in Experimental Parasitology (1989) at Queen’s where he began working on parasite neuromuscular systems. He focused on molecular aspects of parasite neurobiology during postdoctoral positions at Queen’s and at The Upjohn Company in Kalamazoo, MI (USA). Maule returned to Queen’s as a member of academic staff in 1995 to pursue the basic biology of helminth signaling systems. Research interests include parasite neurobiology and the development and exploitation of gene silencing platforms for target validation and parasite control.

Table of contents (11 chapters)

Table of contents (11 chapters)
  • Receptor-Based Discovery Strategies for Insecticides and Parasiticides: A Review

    Pages 1-9

    Woods, Debra (et al.)

  • Nonpeptide Ligands for Peptidergic G Protein-Coupled Receptors

    Pages 10-26

    Geary, Timothy G.

  • Interaction of Mimetic Analogs of Insect Kinin Neuropeptides with Arthropod Receptors

    Pages 27-48

    Nachman, Ronald J. (et al.)

  • Neuropeptides in Helminths: Occurrence and Distribution

    Pages 49-77

    Marks, Nikki J. (et al.)

  • Neuropeptide Physiology in Helminths

    Pages 78-97

    Mousley, Angela (et al.)

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-1-4419-6902-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
  • Institutional customers should get in touch with their account manager
Hardcover $249.99
price for USA in USD
Softcover $219.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Neuropeptide Systems as Targets for Parasite and Pest Control
Editors
  • Timothy G. Geary
  • Aaron Maule
Series Title
Advances in Experimental Medicine and Biology
Series Volume
692
Copyright
2010
Publisher
Springer US
Copyright Holder
Landes Bioscience and Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-6902-6
DOI
10.1007/978-1-4419-6902-6
Hardcover ISBN
978-1-4419-6901-9
Softcover ISBN
978-1-4899-9860-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XVIII, 230
Topics