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Advances in Experimental Medicine and Biology

Sphingolipids as Signaling and Regulatory Molecules

Editors: Chalfant, Charles, Del Poeta, Maurizio (Eds.)

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  • Includes a series of mouse animal models currently available for studying the role of sphingolipids in embryonic development, aging and a series of pathological processes
  • Represents a comprehensive review of the current knowledge of sphingolipid signaling and that research scientists can use it as a reference for their studies
  • Features studies of sphingolipids in different system models
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About this book

This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.

About the authors

CHARLES CHALFANT is a tenured Associate Professor of Biochemistry and Molecular Biology at Virginia Commonwealth University-School of Medicine. He is also a Research Career Scientist in the Veterans Administration based at the Hunter Holmes McGuire Veterans Administration Medical Center in Richmond, Virginia. His main research interests lie in lipid signaling, specifically the role of intracellular lipid second messengers (e.g., ceramide-1-phosphate) in regulating eicosanoid synthesis. He also studies the role of oncogenic signaling pathways in regulating the alternative splicing of tumor suppressor genes such as caspase 9. Dr. Chalfant serves on the Editorial Board of The Journal of Lipid Research as well as on several National Panels of Scientific Review including formal membership on the Cancer Molecular Pathobiology Study Section for the National Institutes of Health and the Oncology A Study Section for the Veterans Administration. He received his PhD degree from the University of South Florida-College of Medicine and did his postdoctoral studies at Duke University and the Medical University of South Carolina. MAURIZIO DEL POETA , MD is a tenured Associate Professor of Biochemistry and Molecular Biology, Microbiology and Immunology, Craniofacial Biology, and for the Division of Infectious Diseases at the Medical University of South Carolina, Charleston, South Carolina, USA. He is also the Director of the Graduate Program in Biochemistry and Molecular Biology at MUSC. Main research interests include the study of the role of sphingolipids in fungal pathogenesis and the development of new diagnostic and therapeutic strategies against fungal infections. He received many awards for his research discoveries and teaching. He is also a member of many national and international societies such as the American Society for Clinical Investigation (ASCI), the American Society for Biochemistry and Molecular Biology, and the American Society for Microbiology. Dr. Del Poeta is a Burroughs Wellcome New Investigator in the Pathogenesis of Infectious Diseases.

Table of contents (19 chapters)

Table of contents (19 chapters)
  • An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown

    Pages 1-23

    Gault, Christopher R. (et al.)

  • Sphingolipid Transport

    Pages 24-45

    Riboni, Laura (et al.)

  • Sphingolipid Analysis by High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS)

    Pages 46-59

    Bielawski, Jacek (et al.)

  • Ceramide Synthases: Roles in Cell Physiology and Signaling

    Pages 60-71

    Stiban, Johnny (et al.)

  • Tales and Mysteries of the Enigmatic Sphingomyelin Synthase Family

    Pages 72-85

    Holthuis, Joost C. M. (et al.)

Buy this book

eBook $219.00
price for USA in USD
  • ISBN 978-1-4419-6741-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-1-4419-6740-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Online orders shipping within 2-3 days.
Softcover $279.99
price for USA in USD
  • ISBN 978-1-4939-5156-7
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Sphingolipids as Signaling and Regulatory Molecules
Editors
  • Charles Chalfant
  • Maurizio Del Poeta
Series Title
Advances in Experimental Medicine and Biology
Series Volume
688
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Landes Bioscience and Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-6741-1
DOI
10.1007/978-1-4419-6741-1
Hardcover ISBN
978-1-4419-6740-4
Softcover ISBN
978-1-4939-5156-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXV, 291
Topics

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