Sphingolipids as Signaling and Regulatory Molecules

1. Front Matter

   Pages i-xxv

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2. An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown

   • Christopher R. Gault, Lina M. Obeid, Yusuf A. Hannun

   Pages 1-23

3. Sphingolipid Transport

   • Laura Riboni, Paola Giussani, Paola Viani

   Pages 24-45

4. Sphingolipid Analysis by High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS)

   • Jacek Bielawski, Jason S. Pierce, Justin Snider, Barbara Rembiesa, Zdzislaw M. Szulc, Alicja Bielawska

   Pages 46-59

5. Ceramide Synthases: Roles in Cell Physiology and Signaling

   • Johnny Stiban, Rotem Tidhar, Anthony H. Futerman

   Pages 60-71

6. Tales and Mysteries of the Enigmatic Sphingomyelin Synthase Family

   • Joost C. M. Holthuis, Chiara Luberto

   Pages 72-85

7. Ceramide in Stress Response

   • Mariana N. Nikolova-Karakashian, Krassimira A. Rozenova

   Pages 86-108

8. Animal Models for Studying the Pathophysiology of Ceramide

   • Toshihiko Kawamori

   Pages 109-117

9. Ceramide-1-Phosphate in Cell Survival and Inflammatory Signaling

   • Antonio Gómez-Muñoz, Patricia Gangoiti, María H. Granado, Lide Arana, Alberto Ouro

   Pages 118-130

10. Ceramide-1-Phosphate in Phagocytosis and Calcium Homeostasis

    • Vania Hinkovska-Galcheva, James A. Shayman

    Pages 131-140

11. Extracellular and Intracellular Actions of Sphingosine-1-Phosphate

    • Graham M. Strub, Michael Maceyka, Nitai C. Hait, Sheldon Milstien, Sarah Spiegel

    Pages 141-155

12. Glucosylceramide in Humans

    • Maria C. Messner, Myles C. Cabot

    Pages 156-164

13. Gangliosides as Regulators of Cell Membrane Organization and Functions

    • Sandro Sonnino, Alessandro Prinetti

    Pages 165-184

14. Cancer Treatment Strategies Targeting Sphingolipid Metabolism

    • Babak Oskouian, Julie D. Saba

    Pages 185-205

15. Therapeutic Strategies for Diabetes and Complications: A Role for Sphingolipids?

    • Todd E. Fox, Mark Kester

    Pages 206-216

16. Roles for Sphingolipids in Saccharomyces cerevisiae

    • Robert C. Dickson

    Pages 217-231

17. Sphingolipid Signaling in Fungal Pathogens

    • Ryan Rhome, Maurizio Del Poeta

    Pages 232-237

18. Sphingolipids in Parasitic Protozoa

    • Kai Zhang, James D. Bangs, Stephen M. Beverley

    Pages 238-248

19. Biosynthesis of Sphingolipids in Plants (and Some of Their Functions)

    • Simone Zäuner, Philipp Ternes, Dirk Warnecke

    Pages 249-263

20. Computational Analysis of Sphingolipid Pathway Systems

    • Eberhard O. Voit, Fernando Alvarez-Vasquez, Yusuf A. Hannun

    Pages 264-275

This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.

• Asthma
• Chalfant
• Del Poeta
• Migration
• Molecule
• Signaling
• Sphingolipid
• infectious disease
• pathophysiology
• physiology
• tissue

• Department of Biochemistry, Virginia Commonwealth University, Richmond, USA

  Charles Chalfant

• Department of Biochemistry, Medical University of South Carolina, Charleston, USA

  Maurizio Del Poeta

CHARLES CHALFANT is a tenured Associate Professor of Biochemistry and Molecular Biology at Virginia Commonwealth University-School of Medicine. He is also a Research Career Scientist in the Veterans Administration based at the Hunter Holmes McGuire Veterans Administration Medical Center in Richmond, Virginia. His main research interests lie in lipid signaling, specifically the role of intracellular lipid second messengers (e.g., ceramide-1-phosphate) in regulating eicosanoid synthesis. He also studies the role of oncogenic signaling pathways in regulating the alternative splicing of tumor suppressor genes such as caspase 9. Dr. Chalfant serves on the Editorial Board of The Journal of Lipid Research as well as on several National Panels of Scientific Review including formal membership on the Cancer Molecular Pathobiology Study Section for the National Institutes of Health and the Oncology A Study Section for the Veterans Administration. He received his PhD degree from the University of South Florida-College of Medicine and did his postdoctoral studies at Duke University and the Medical University of South Carolina. MAURIZIO DEL POETA , MD is a tenured Associate Professor of Biochemistry and Molecular Biology, Microbiology and Immunology, Craniofacial Biology, and for the Division of Infectious Diseases at the Medical University of South Carolina, Charleston, South Carolina, USA. He is also the Director of the Graduate Program in Biochemistry and Molecular Biology at MUSC. Main research interests include the study of the role of sphingolipids in fungal pathogenesis and the development of new diagnostic and therapeutic strategies against fungal infections. He received many awards for his research discoveries and teaching. He is also a member of many national and international societies such as the American Society for Clinical Investigation (ASCI), the American Society for Biochemistry and Molecular Biology, and the American Society for Microbiology. Dr. Del Poeta isa Burroughs Wellcome New Investigator in the Pathogenesis of Infectious Diseases.

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