Overview
- First book to focus on patient-specific modeling of the heart
- This book covers the design of a variety of patient-specific models within the cardiovascular system in computational biology
- Focus on the potential of patient-specific computational models of cardiovascular physiology to predict or optimize outcomes of clinical treatments
- Includes supplementary material: sn.pub/extras
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About this book
Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.
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Table of contents (12 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: Patient-Specific Modeling of the Cardiovascular System
Book Subtitle: Technology-Driven Personalized Medicine
Editors: Roy C.P. Kerckhoffs
DOI: https://doi.org/10.1007/978-1-4419-6691-9
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media, LLC 2010
Hardcover ISBN: 978-1-4419-6690-2Published: 09 September 2010
Softcover ISBN: 978-1-4899-8242-1Published: 19 October 2014
eBook ISBN: 978-1-4419-6691-9Published: 03 September 2010
Edition Number: 1
Number of Pages: XXI, 240
Topics: Bioinformatics, Computational Biology/Bioinformatics, Biomedical Engineering and Bioengineering, Cardiology