Overview
- Editors:
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Rebecca G. Bagley
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Genzyme Corporation, Framingham, USA
- Explains role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination
- Represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment
- In-depth chapters written by known professionals in the field
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Table of contents (32 chapters)
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Front Matter
Pages i-xviii
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Physiological Parameters
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- Annamaria Rapisarda, Giovanni Melillo
Pages 3-21
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- Pawel Swietach, Adrian L. Harris, Richard D. Vaughan-Jones
Pages 23-41
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- Olga V. Razorenova, Amato J. Giaccia
Pages 43-58
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- Jaromir Pastorek, Silvia Pastorekova
Pages 59-90
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Malignant Cells
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Front Matter
Pages 119-119
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- Mark R. Kelley, Millie M. Georgiadis, Melissa L. Fishel
Pages 133-168
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- Mario Federico, Antonio Giordano
Pages 169-185
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- Douglas M. Noonan, Giuseppina Pennesi, Adriana Albini
Pages 213-228
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- Paloma Bragado, Aparna C. Ranganathan, Julio A. Aguirre-Ghiso
Pages 229-254
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Vasculature And Stroma
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Front Matter
Pages 255-255
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- Robert S. Kerbel, Francesco Bertolini, Yuval Shaked
Pages 257-273
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- Pravin J. Mishra, Debabrata Banerjee
Pages 275-288
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- Koji Matsuo, Chunhua Lu, Mian M. K. Shazad, Robert L. Coleman, Anil K. Sood
Pages 311-323
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- Urszula M. Polanska, Kieran T. Mellody, Akira Orimo
Pages 325-349
About this book
The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and invaded local sites. Today, there is an increased understanding of the critical role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination. This volume represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment in cancer development and progression. Perhaps, the earliest recognition of the role of nonmalignant cells as cancer re- lators was the recognition that lymphocytes can participate in what was termed “immune surveillance” in the 1960s. Our understanding of tumor immunity has improved markedly since then, and there are now successful clinical studies sh- ing the potential use of immune-based therapies in cancer treatment.
Editors and Affiliations
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Genzyme Corporation, Framingham, USA
Rebecca G. Bagley
About the editor
Rebecca Bagley is a senior scientist at Genzyme Corporation and has worked in the biotechnology industry for 20 years with degrees in biology from Wellesley College and Harvard University. Her expertise in drug development spans a wide range of approaches including immunotherapies, gene and protein therapies, and small molecule delivery with publications in journals such as Molecular Cancer Therapeutics, Cancer Research, and Microvascular Research . Her current research focuses on stem cells, tumor vasculature, and target validation.
