Name: Advances in TNF Family Research
ISBN: 978-1-4419-6612-4

Editors:

David Wallach⁰,
Andrew Kovalenko¹,
Marc Feldmann²

David Wallach
1. Dept. Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
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Andrew Kovalenko
1. Dept. Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
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Marc Feldmann
1. Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom
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Most up-to-date book on current research of the TNF family
TNF meetings follow the enormous progress in this field
The conference focused on the physiological, pathophysiological, and medical significance of these important regulators
Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 691)

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Table of contents (66 papers)

Front Matter

Pages i-xxxvi

PDF
Roles of the TNF Family in Tissue Homeostasis and Normal Development
1. Front Matter
  
  Pages 1-1
  
  PDF
2. Workshop Summary: Roles of the TNF Family in Normal Development and Cancer
  
  Nancy H. Ruddle
  
  Pages 3-4
3. TNF Conference 2009: Beyond Bones – RANKL/RANK in the Immune System
  
  Andreas Leibbrandt, Josef M. Penninger
  
  Pages 5-22
4. The Edar Subfamily in Hair and Exocrine Gland Development
  
  Marja L. Mikkola
  
  Pages 23-33
5. High Endothelial Venule Reporter Mice to Probe Regulation of Lymph Node Vasculature
  
  Kevin L. Bentley, Sharon Stranford, Shan Liao, Rawad M. Mounzer, Frank H. Ruddle, Nancy H. Ruddle
  
  Pages 35-44
6. Eiger and Wengen: The Drosophila Orthologs of TNF/TNFR
  
  Tatsushi Igaki, Hiroshi Kanda, Hideyuki Okano, Tian Xu, Masayuki Miura
  
  Pages 45-50
Novel Aspects of Signaling Activation by the TNF Family: Novel Aspects of the Functions of the TRAFs and cIAPs
1. Front Matter
  
  Pages 51-51
  
  PDF
Novel Aspects of Signaling Activation by the TNF Family: Novel Aspects of the Functions of the TRAFs and cIAPs
1. Workshop Summary: Novel Aspects of the Functions of the TRAFs and cIAPs
  
  John Silke, Domagoj Vucic
  
  Pages 53-61
2. TRAF2 and Cellular IAPs: A Critical Link in TNFR Family Signaling
  
  Domagoj Vucic
  
  Pages 63-78
3. New Perspectives in TNF-R1-Induced NF-κB Signaling
  
  Ian E. Gentle, John Silke
  
  Pages 79-88
4. Structural Studies of NEMO and TRAF6: Implications in NF-κB Activation
  
  Hao Wu, Yu-Chih Lo, Qian Yin
  
  Pages 89-91
Novel Aspects of Signaling Activation by the TNF: Ubiquitin Modification of Signaling Proteins
1. Front Matter
  
  Pages 93-93
  
  PDF
Novel Aspects of Signaling Activation by the TNF : Ubiquitin-Modification of Signaling Proteins
1. Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination Is Sufficient for Proteasomal Processing of the p105 NF-κB Precursor
  
  Yelena Kravtsova-Ivantsiv, Shai Cohen, Aaron Ciechanover
  
  Pages 95-106
2. Selective Binding of Linear Ubiquitin Chains to NEMO in NF-kappaB Activation
  
  Fumiyo Ikeda, Simin Rahighi, Soichi Wakatsuki, Ivan Dikic
  
  Pages 107-114
3. The Linear Ubiquitin Chain Assembly Complex (LUBAC) Forms Part of the TNF-R1 Signalling Complex and Is Required for Effective TNF-Induced Gene Induction and Prevents TNF-Induced Apoptosis
  
  Christoph H. Emmerich, Anna C. Schmukle, Tobias L. Haas, Björn Gerlach, Stefanie M. Cordier, Eva Rieser et al.
  
  Pages 115-126
4. Temporal Control of TNFα Signaling by Miz1
  
  Anning Lin
  
  Pages 127-128
Novel aspects of Signaling Activation by the TNF Family: TNF Signaling and Gene Regulatory Networks
1. Front Matter
  
  Pages 129-129
  
  PDF
Novel aspects of Signaling Activation by the TNF Family: TNF Signaling- and gene Regulatory-Networks
1. Large-Scale RNAi Screens to Dissect TNF and NF-κB Signaling Pathways
  
  Marie Metzig, Dorothee Nickles, Michael Boutros
  
  Pages 131-139
2. Pathogenic Role of IL-6 Combined with TNF-α or IL-1 in the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases
  
  Kazuyuki Yoshizaki
  
  Pages 141-150

About this book

The biennial TNF-family conferences have been held over the past 20 years, from the time that TNF was cloned. These meetings have followed the enormous progress in this field. Much is now known about the members of the TNF ligand and receptor families, their signaling proteins, mechanisms of action and cellular functions. This volume is the proceedings of the 12th TNF International Conference, held in April 2009. This conference focuses on the physiological, pathophysiological, and medical significance of these important regulators. Sessions at the meeting specifically address their involvement in immunity, development, apoptosis, autoimmunity, cancer, and infection, the normal function and pathology of the neuronal system, as well as major unresolved questions about their mechanisms of action.

Editors and Affiliations

Dept. Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

David Wallach, Andrew Kovalenko
Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom

Marc Feldmann

Bibliographic Information

Book Title: Advances in TNF Family Research
Book Subtitle: Proceedings of the 12th International TNF Conference, 2009
Editors: David Wallach, Andrew Kovalenko, Marc Feldmann
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4419-6612-4
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2011
Hardcover ISBN: 978-1-4419-6611-7Published: 10 December 2010
Softcover ISBN: 978-1-4614-2783-4Published: 31 January 2013
eBook ISBN: 978-1-4419-6612-4Published: 09 December 2010
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XXXVI, 844
Topics: Immunology, Microbiology, Biomedicine general

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Table of contents (66 papers)

Front Matter

Roles of the TNF Family in Tissue Homeostasis and Normal Development

Front Matter

Novel Aspects of Signaling Activation by the TNF Family: Novel Aspects of the Functions of the TRAFs and cIAPs

Front Matter

Novel Aspects of Signaling Activation by the TNF Family: Novel Aspects of the Functions of the TRAFs and cIAPs

Novel Aspects of Signaling Activation by the TNF: Ubiquitin Modification of Signaling Proteins

Front Matter

Novel Aspects of Signaling Activation by the TNF : Ubiquitin-Modification of Signaling Proteins

Novel aspects of Signaling Activation by the TNF Family: TNF Signaling and Gene Regulatory Networks

Front Matter

Novel aspects of Signaling Activation by the TNF Family: TNF Signaling- and gene Regulatory-Networks

About this book

Editors and Affiliations

Dept. Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom

Bibliographic Information

Publish with us

Buy it now

Buying options

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